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SNAP29 Antibodies
AND SNAP29 ELISA kits, SNAP29 Proteins
Many biological assays use antibodies to detect SNAP29, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SNAP29 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SNAP29 antibodies...
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SNAP29 Overview
Facts about Synaptosomal-associated protein 29.
Synaptosomal-associated protein 29 (SNAP29)
SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical package that drives membrane fusion.
SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions.
Gene Information
| Human | |
|---|---|
| Gene Name: | SNAP29 |
| Uniprot: | O95721 |
| Entrez: | 9342 |
Family
| Belongs to: |
|---|
| SNAP-25 family |
Alternative Names
CEDNIK; CEDNIKSoluble 29 kDa NSF attachment protein; SNAP29; SNAP-29FLJ21051; synaptosomal-associated protein 29; synaptosomal-associated protein, 29kD; synaptosomal-associated protein, 29kDa; Vesicle-membrane fusion protein SNAP-29
Molecular Weight
Mass (kDA):
28.97 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q11.21 |
| Sequence: | 22; NC_000022.11 (20859007..20891214) |
Tissue Specificity
Found in brain, heart, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.
Subcellular Localizations
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Cell projection, cilium membrane; Peripheral membrane protein. Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is cytoplasmic. Localizes to the ciliary pocket from where the cilium protrudes.
Diseases
- Congenital Abnormality
- Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndrome
- Nervousness
- Ichthyoses
- Palmoplantar Keratosis
- Schizophrenia
- Neurocutaneous Syndromes
- Mental Disorders
- Depressive Disorder
- Digeorge Syndrome
- Urogenital Abnormalities
Interacting Proteins
- FAM9B
- NAPB
- OGT
- STX12
- STX17
- STX1A
- STX6
- TRAF3
- VAMP1
- VAMP2
Pathways
- Transport
- Membrane Fusion
- Localization
- Secretion
- Endocytic Recycling
- Synaptic Transmission
- Endocytosis
- Snare Complex Disassembly
- Vesicle Fusion
- Myelination
- Exocytosis
- Receptor-mediated Endocytosis
- Keratinization
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SNAP29
bosterbio.com/bosterbio-gene-info-cards/SNAP29
References
PMID: 9852078 by Steegmaier M., et al. Three novel proteins of the syntaxin/SNAP-25 family.
PMID: 15968592 by Sprecher E., et al. A mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma.