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SMUG1 Antibodies
AND SMUG1 ELISA kits, SMUG1 Proteins
Many biological assays use antibodies to detect SMUG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMUG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMUG1 antibodies...
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SMUG1 Overview
Facts about Single-strand selective monofunctional uracil DNA glycosylase.
Single-strand selective monofunctional uracil DNA glycosylase (SMUG1)
Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates.
The action is greater toward mismatches (U/G) compared to games (U/A). Excises uracil (U), 5- formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5- hydroxycytosine and 5-formylcytosine), nor other oxidized bases.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMUG1 |
| Uniprot: | Q53HV7 |
| Entrez: | 23583 |
Family
| Belongs to: |
|---|
| uracil-DNA glycosylase (UDG) superfamily |
Alternative Names
EC 3.2.2; EC 3.2.2.-; FDG; HMUDG; MGC104370; single-strand selective monofunctional uracil DNA glycosylase; single-strand-selective monofunctional uracil-DNA glycosylase 1; UNG3
Molecular Weight
Mass (kDA):
29.862 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.13 |
| Sequence: | 12; NC_000012.12 (54121274..54188994, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Lymphoma
- Adenocarcinoma
- Multiple Transition Abnormalities
- Genomic Instability
- Microsatellite Instability
- Rectal Neoplasms
- Infective Disorder
- Hyperplasia
- Stomach Neoplasms
- Mutation Abnormality
Interacting Proteins
- CDC23
- CRX
- KRTAP13-2
- RBPMS
- SKIL
- VAC14
Pathways
- Dna Repair
- Dna Replication
- Mismatch Repair
- Cell Cycle
- Pathogenesis
- Dna Deamination
- Cell Cycle Arrest
- Cell Proliferation
- Cell Killing
- Immune Response
- Cytidine Deamination
PTMs
- Deamination
- Oxidation
Research Areas
- Base Excision Repair
- Cancer
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMUG1
bosterbio.com/bosterbio-gene-info-cards/SMUG1
References
PMID: 10074426 by Haushalter K.A., et al. Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors.
PMID: 12718543 by Masaoka A., et al. Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.