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- Table of Contents
Facts about Protein SMG7.
Together with SMG5 is thought to give a link to the mRNA degradation machinery involving exonucleolytic pathways, and also to function as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. .
Human | |
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Gene Name: | SMG7 |
Uniprot: | Q92540 |
Entrez: | 9887 |
Belongs to: |
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No superfamily |
breast cancer-associated antigen SGA-56M; C1orf16; chromosome 1 open reading frame 16; EST1 telomerase component homolog C; EST1CKIAA0250SGA56M; EST1-like protein C; ever shorter telomeres 1C; FLJ23717; hSMG-7; protein SMG7; SMG-7 homolog; Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans); SMG-7
Mass (kDA):
127.282 kDA
Human | |
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Location: | 1q25.3 |
Sequence: | 1; NC_000001.11 (183471993..183554193) |
Cytoplasm. Nucleus. Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.
PMID: 14636577 by Ohnishi T., et al. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.
PMID: 15546618 by Unterholzner L., et al. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.