Protein SMG7 (SMG7)

Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies.

Together with SMG5 is thought to give a link to the mRNA degradation machinery involving exonucleolytic pathways, and also to function as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. .