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SMC4 Antibodies
AND SMC4 ELISA kits, SMC4 Proteins
Many biological assays use antibodies to detect SMC4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMC4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMC4 antibodies...
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SMC4 Infographic by Boster Bio
All SMC4 Products
Product
Figures
Specificity
Applications
Price
Anti-SMC4 Antibody Picoband®
1 Q&As
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A04887-1
100 μg/vial
Cat # A04887-1
100 μg/vial
Human, Mouse
Flow Cytometry, IF, ICC, WB
$370
Cat # M04887
100 μl/vial
Cat # M04887
100 μl/vial
SMC4 Overview
Facts about Structural maintenance of chromosomes protein 4.
Structural maintenance of chromosomes protein 4 (SMC4)
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
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Gene Information
| Human | |
|---|---|
| Gene Name: | SMC4 |
| Uniprot: | Q9NTJ3 |
| Entrez: | 10051 |
Family
| Belongs to: |
|---|
| SMC family |
Alternative Names
CAP-C; CAPCSMC4 structural maintenance of chromosomes 4-like 1 (yeast); Chromosome-associated polypeptide C; hCAP-CSMC4 (structural maintenance of chromosomes 4, yeast)-like 1; SMC protein 4; SMC4 structural maintenance of chromosomes 4-like 1; SMC-4; SMC4L1; structural maintenance of chromosomes 4; structural maintenance of chromosomes protein 4; XCAP-C homolog
Molecular Weight
Mass (kDA):
147.182 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q25.33 |
| Sequence: | 3; NC_000003.12 (160399638..160434953) |
Tissue Specificity
Widely expressed. Higher expression in testis, colon, thymus.
Subcellular Localizations
Nucleus. Cytoplasm. Chromosome. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase
Diseases
- Neoplasms
- Cell Transformation, Neoplastic
- Malignant Neoplasms
- Mammary Neoplasms
- Cell Invasion
- Mitochondrial Dna Depletion
- Liver Carcinoma
- Malignant Neoplasm Of Breast
- Glioma
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Liver
- Malignant Glioma
Interacting Proteins
- NCAPH
- NCAPH2
- SMC2
Pathways
- Chromosome Condensation
- Mitosis
- Dna Repair
- Metaphase
- Cell Cycle
- Sister Chromatid Cohesion
- Interphase
- Chromosome Segregation
- Cell Division
- Localization
- Mitotic Chromosome Condensation
- Dosage Compensation
- Dna Recombination
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
- Core ESC-Like Genes
- DNA Repair
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMC4
bosterbio.com/bosterbio-gene-info-cards/SMC4
References
PMID: 10319587 by Nishiwaki T., et al. Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family.
PMID: 9789013 by Schmiesing J.A., et al. Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.