SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1)

Part of SWI/SNF chromatin remodeling complexes that carry out crucial enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) as well as the neuron-specific chromatin remodeling complex (nBAF complex).

During neural development a switch from a stem/progenitor into a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult condition. The transition from proliferating neural stem/progenitor cells into postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.