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- Table of Contents
Facts about SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1.
The BAF complex is able to make a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of around one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers.
Human | |
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Gene Name: | SMARCB1 |
Uniprot: | Q12824 |
Entrez: | 6598 |
Belongs to: |
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SNF5 family |
BAF47; BAF47hSNF5; BRG1-associated factor 47; hSNFS; Ini1; INI1RTPS1; Integrase interactor 1 protein; malignant rhabdoid tumor suppressor; RDTSNF5 homolog; Sfh1p; SNF5; SNF5L1; Snr1; subfamily b, member 1; sucrose nonfermenting, yeast, homolog-like 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin; SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily B member 1
Mass (kDA):
44.141 kDA
Human | |
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Location: | 22q11.23|22q11 |
Sequence: | 22; NC_000022.11 (23786966..23838009) |
Nucleus.
PMID: 7801128 by Kalpana G.V., et al. Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5.
PMID: 9671307 by Versteege I., et al. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.