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SMAD7 Antibodies
AND SMAD7 ELISA kits, SMAD7 Proteins
Many biological assays use antibodies to detect SMAD7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMAD7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMAD7 antibodies...
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SMAD7 Overview
Facts about Mothers against decapentaplegic homolog 7.
Mothers against decapentaplegic homolog 7 (SMAD7)
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been demonstrated to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex.
Additionally acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which functions as a negative regulator.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMAD7 |
| Uniprot: | O15105 |
| Entrez: | 4092 |
Family
| Belongs to: |
|---|
| dwarfin/SMAD family |
Alternative Names
CRCS3; FLJ16482; hSMAD7; MAD homolog 7; MAD homolog 8; MAD, mothers against decapentaplegic homolog 7 (Drosophila); MADH7; MADH7mothers against decapentaplegic homolog 7; MADH8; Mothers against decapentaplegic homolog 8; Mothers against decapentaplegic, drosophila, homolog of, 7; Mothers against DPP homolog 7; Mothers against DPP homolog 8; SMAD 7; SMAD family member 7MAD (mothers against decapentaplegic, Drosophila) homolog 7; SMAD, mothers against DPP homolog 7 (Drosophila); SMAD, mothers against DPP homolog 7; Smad7
Molecular Weight
Mass (kDA):
46.426 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q21.1 |
| Sequence: | 18; NC_000018.10 (48919853..48950711, complement) |
Tissue Specificity
Ubiquitous with higher expression in the lung and vascular endothelium.
Subcellular Localizations
Nucleus. Cytoplasm. Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236).
Diseases
- Fibrosis
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Kidney Diseases
- Carcinoma
- Hepatic Fibrosis
- Liver Cirrhosis
- Cell Transformation, Neoplastic
- Hypertrophy
- Tissue Adhesions
- Colorectal Cancer
- Kidney Fibrosis
Interacting Proteins
- ACVR1B
- AXIN1
- COPS5
- FKBP1A
- Rnf111
- SMURF2
- WWP2
- YAP1
Pathways
- Pathogenesis
- Cell Proliferation
- Localization
- Wound Healing
- Cell Growth
- Cell Cycle
- Secretion
- Transdifferentiation
- Cell Differentiation
- Cell Death
- Rna Interference
- Reverse Transcription
- Angiogenesis
PTMs
- Phosphorylation
- Ubiquitination
- Acetylation
- Cleavage
- Dephosphorylation
- Deacetylation
- Methylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMAD7
bosterbio.com/bosterbio-gene-info-cards/SMAD7
References
PMID: 9215638 by Hayashi H., et al. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.
PMID: 9256479 by Topper J.N., et al. Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium.
2 Publications of Boster SMAD7 Antibodies & ELISA Kits
- PubMed ID: 10.1371/journal.pone.0153409, Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induce...
- PubMed ID: 10.1016/j.jep.2019.112404, Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathw...
*More publications can be found for each product on its corresponding product page