SMAD6 Antibodies

AND SMAD6 ELISA kits, SMAD6 Proteins

Many biological assays use antibodies to detect SMAD6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMAD6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMAD6 antibodies...

We validate the specificity of these antibodies to SMAD6 by testing them on tissues known to express SMAD6 positively and negatively. Browse below to find the SMAD6 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SMAD6 Infographic by Boster Bio

All SMAD6 Products

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Specificity

Applications

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Anti-Smad6 Antibody

1 Citations

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A02227
100ul

Anti-Smad6 Antibody

Human, Mouse

ELISA, IHC, WB

$380
Cat # A02227-1
100ul

Anti-Smad6 Monoclonal Antibody

Human

ELISA, WB

$380
Cat # M02227
100ul

SMAD6 Overview

Facts about Mothers against decapentaplegic homolog 6.

SMAD6 3D structure. Source: alphafold

Mothers against decapentaplegic homolog 6 (SMAD6)

Acts as a mediator of TGF-beta and BMP antiflammatory activity.
Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.

May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.

Gene Information

Human
Gene Name:	SMAD6
Uniprot:	O43541
Entrez:	4091

Family

Belongs to:

dwarfin/SMAD family

Alternative Names

hSMAD6; HsT17432; MAD homolog 6; MADH6SMAD, mothers against DPP homolog 6 (Drosophila); MADH7; mothers against decapentaplegic homolog 6; Mothers against decapentaplegic, drosophila, homolog of, 6; Mothers against DPP homolog 6; SMAD 6; SMAD family member 6MAD, mothers against decapentaplegic homolog 6 (Drosophila); SMAD, mothers against DPP homolog 6; Smad6

Molecular Weight

Mass (kDA):
53.497 kDA

Genomic Context


Human

Location:	15q22.31
Sequence:	15; NC_000015.10 (66702110..66782849)

Tissue Specificity

Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Fibrosis
Malignant Paraganglionic Neoplasm
Cell Transformation, Neoplastic
Hypertrophy
Inflammation
Kidney Diseases
Tissue Adhesions
Pancreatic Neoplasm
Carcinogenesis
Nervousness

Hypertensive Disease
Growth Arrest
Pulmonary Hypertension
Adenocarcinoma
Malignant Squamous Cell Neoplasm
Idiopathic Pulmonary Hypertension
Lung Diseases

Interacting Proteins

PRKX
RUNX2
SMAD1
STAMBP

Pathways

Cell Proliferation
Pathogenesis
Cell Growth
Cell Differentiation
Localization
Rna Interference
Secretion
Osteoblast Differentiation
Cell Cycle
Chondrocyte Differentiation
Ossification
Gastrulation
Bmp Signaling Pathway

Translation
Cartilage Development
Cell Death
Chondrocyte Proliferation
Angiogenesis
Endochondral Ossification
Regeneration

PTMs

Phosphorylation
Ubiquitination
Methylation
Demethylation
Cleavage

Acetylation
Sumoylation
Gamma-carboxylation
Dephosphorylation
Geranylgeranylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMAD6

References

PMID: 8673135 by Riggins G.J., et al. Mad-related genes in the human.

PMID: 9436979 by Hata A., et al. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor.

1 Publications of Boster SMAD6 Antibodies & ELISA Kits

PubMed ID: 27019660, Effect of Kuijie Granule on the Expression of TGF-?/Smads Signaling Pathway in P...

*More publications can be found for each product on its corresponding product page