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SMAD2 Antibodies
AND SMAD2 ELISA kits, SMAD2 Proteins
Many biological assays use antibodies to detect SMAD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMAD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMAD2 antibodies...
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SMAD2 Infographic by Boster Bio
All SMAD2 Products
Product
Figures
Specificity
Applications
Price
Anti-Phospho-Smad2 (S250) Rabbit Monoclonal Antibody
4 Citations 5 Q&As
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # P00090-1
100 μl
Cat # P00090-1
100 μl
Anti-Phospho-Smad2 (S255) Rabbit Monoclonal Antibody
3 Citations 4 Q&As
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # P00090
100 μl
Cat # P00090
100 μl
Anti-Smad2 Rabbit Monoclonal Antibody
3 Citations 16 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M00090-1
100 μl
Cat # M00090-1
100 μl
Anti-Smad2 Rabbit Monoclonal Antibody
2 Citations 16 Q&As
Human, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00090
100 μl
Cat # M00090
100 μl
Anti-SMAD2 Antibody Picoband®
3 Citations 16 Q&As
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00090-1
100 μg/vial
Cat # A00090-1
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1527
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1527
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1959
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1959
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2273
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2273
1 kit, containing two 96-well plates and all necessary reagents
Human
Flow Cytometry, IHC, WB
$370
Cat # M00090-3
100 μg/vial
Cat # M00090-3
100 μg/vial
SMAD2 Overview
Facts about Mothers against decapentaplegic homolog 2.
Mothers against decapentaplegic homolog 2 (SMAD2)
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription.
May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which functions as a negative regulator.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMAD2 |
| Uniprot: | Q15796 |
| Entrez: | 4087 |
Family
| Belongs to: |
|---|
| dwarfin/SMAD family |
Alternative Names
hMAD-2; hSMAD2; JV18; JV18-1SMAD, mothers against DPP homolog 2 (Drosophila); MAD homolog 2; Mad protein homolog; Mad, mothers against decapentaplegic homolog 2; MADH2MGC34440; MADR2MGC22139; Mad-related protein 2; mother against DPP homolog 2; mothers against decapentaplegic homolog 2; Mothers against DPP homolog 2; Sma- and Mad-related protein 2; SMAD 2; SMAD family member 2MAD, mothers against decapentaplegic homolog 2 (Drosophila); SMAD, mothers against DPP homolog 2; Smad2; Smad2/3
Molecular Weight
Mass (kDA):
52.306 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q21.1 |
| Sequence: | 18; NC_000018.10 (47808957..47931188, complement) |
Tissue Specificity
Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081).
Diseases
- Malignant Neoplasms
- Fibrosis
- Neoplasms
- Carcinoma
- Inflammation
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Kidney Diseases
- Cell Invasion
- Malignant Paraganglionic Neoplasm
- Tissue Adhesions
- Hypertrophy
- Carcinogenesis
Interacting Proteins
- ANK3
- CHGB
- CHUK
- DAB2
- DOCK9
- FOXH1
- JUN
- MTMR4
- NEFM
- OLIG1
Pathways
- Cell Proliferation
- Localization
- Pathogenesis
- Cell Growth
- Secretion
- Cell Cycle
- Angiogenesis
- Wound Healing
- Cell Migration
- Cell Differentiation
- Cell Death
- Gastrulation
- Regeneration
PTMs
- Phosphorylation
- Ubiquitination
- Dephosphorylation
- Acetylation
- Methylation
- Cleavage
- Demethylation
- Reduction
- Oxidation
- Sumoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMAD2
bosterbio.com/bosterbio-gene-info-cards/SMAD2
References
PMID: 8673135 by Riggins G.J., et al. Mad-related genes in the human.
PMID: 8774881 by Zhang Y., et al. Receptor-associated Mad homologues synergize as effectors of the TGF- beta response.
7 Publications of Boster SMAD2 Antibodies & ELISA Kits
- PubMed ID: 10.1155/2016/2601830, Effect of Kuijie Granule on the Expression of TGF-β/Smads Signaling Pathway in ...
- PubMed ID: 34093874, Wang Q,Liu J,Hu Y,Pan T,Xu Y,Yu J,Xiong W,Zhou Q,Wang Y.Local administration of ...
- PubMed ID: 33179312, Zhao B,Li S,Guo Z,Chen Z,Zhang X,Xu C,Chen J,Wei C. Dopamine receptor D2 inhibit...
- PubMed ID: 30090338, Mouse hepatic neoplasm formation induced by trace level and low frequency exposu...
- PubMed ID: 26261569, Astragaloside effect on TGF-%u03B21, SMAD2/3, and %u03B1-SMA expression in the k...
- PubMed ID: 27019660, Effect of Kuijie Granule on the Expression of TGF-?/Smads Signaling Pathway in P...
- PubMed ID: 21693312, Tao Y, Hu L, Li S, Liu Q, Wu X, Li D, Fu P, Wei D, Luo Z. Transplant Proc. 2011 ...
*More publications can be found for each product on its corresponding product page