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Slit homolog 2 protein Antibodies
AND SLIT2 ELISA kits, Slit homolog 2 protein Proteins
Many biological assays use antibodies to detect Slit homolog 2 protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Slit homolog 2 protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Slit homolog 2 protein antibodies...
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SLIT2 Infographic by Boster Bio
All SLIT2 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$499
Cat # EK1860
96 wells/kit, with removable strips.
Cat # EK1860
96 wells/kit, with removable strips.
SLIT2 Overview
Facts about Slit homolog 2 protein.
Slit homolog 2 protein (SLIT2)
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions.
SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as gruesome signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons when they reached the floor plate by modulating the response to netrin.
Gene Information
| Human | |
|---|---|
| Gene Name: | SLIT2 |
| Uniprot: | O94813 |
| Entrez: | 9353 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FLJ14420; SLIL3; slit (Drosophila) homolog 2; slit homolog 2 (Drosophila); slit homolog 2 protein; Slit2; Slit-2SLIL3
Molecular Weight
Mass (kDA):
169.87 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p15.31 |
| Sequence: | 4; NC_000004.12 (20251905..20620561) |
Tissue Specificity
Fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid, trachea and other tissues examined.
Subcellular Localizations
Secreted. The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated.
Diseases
- Malignant Neoplasms
- Neoplasms
- Nervousness
- Carcinoma
- Tumor Angiogenesis
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Cell Invasion
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
- Colorectal Cancer
- Malignant Neoplasm Of Lung
- Lung Neoplasms
Interacting Proteins
- ROBO1
Pathways
- Axon Guidance
- Cell Migration
- Methylation
- Angiogenesis
- Chemotaxis
- Dna Methylation
- Cell Proliferation
- Tube Formation
- Cell Growth
- Cell Motility
- Endothelial Cell Migration
- Leukocyte Chemotaxis
- Pathogenesis
PTMs
- Methylation
- Demethylation
- Cleavage
- Phosphorylation
Research Areas
- Growth and Development
- Neuronal Cell Markers
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLIT2
bosterbio.com/bosterbio-gene-info-cards/SLIT2
References
PMID: 9813312 by Itoh A., et al. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.
PMID: 10349621 by Holmes G.P., et al. Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis.