Slit homolog 1 protein Antibodies

AND SLIT1 ELISA kits, Slit homolog 1 protein Proteins

Many biological assays use antibodies to detect Slit homolog 1 protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Slit homolog 1 protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Slit homolog 1 protein antibodies...

We validate the specificity of these antibodies to Slit homolog 1 protein by testing them on tissues known to express SLIT1 positively and negatively. Browse below to find the SLIT1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLIT1 Infographic by Boster Bio

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SLIT1 (NM_003061) Human Over-expression Lysate

Human

$960
Cat # LS006585
100 µg

SLIT1 Overview

Facts about Slit homolog 1 protein.

SLIT1 3D structure. Source: alphafold

Slit homolog 1 protein (SLIT1)

Thought to act as molecular guidance cue in cellular migration, and function seems to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different areas (By similarity).

SLIT1 and SLIT2 together appear to be essential for midline guidance in the forebrain by acting as gruesome signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. .

Gene Information

Human
Gene Name:	SLIT1
Uniprot:	O75093
Entrez:	6585

Family

Belongs to:

No superfamily

Alternative Names

KIAA0813; MEGF4; MEGF4slit (Drosophila) homolog 1; MGC164811; Multiple EGF-like domains protein 4; Multiple epidermal growth factor-like domains protein 4; SLIL1; slit homolog 1 (Drosophila); slit homolog 1 protein; Slit1; Slit-1slit1; SLIT3

Molecular Weight

Mass (kDA):
167.926 kDA

Genomic Context


Human

Location:	10q24.1
Sequence:	10; NC_000010.11 (96998038..97185959, complement)

Tissue Specificity

Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney.

Subcellular Localizations

Secreted.

Diseases

Nervousness
Malignant Neoplasms
Neoplasms
Colorectal Cancer
Muscular Fasciculation
Cell Transformation, Neoplastic
Tumor Angiogenesis
Tissue Adhesions
Crest Syndrome
Glioma
Carcinoma
Mammary Neoplasms
Peripheral Nerve Injuries

Congenital Absence
Congenital Abnormality
Liver Carcinoma
Nerve Damage
Neoplasm Metastasis
Spinal Cord Injuries
Malignant Neoplasm Of Breast

Pathways

Axon Guidance
Cell Migration
Methylation
Regeneration
Neurogenesis
Retinal Ganglion Cell Axon Guidance
Angiogenesis
Cell Adhesion
Corpus Callosum Development
Cell Proliferation
Dna Methylation
Endothelial Cell Migration
Innervation

Chemotaxis
Olfactory Bulb Axon Guidance
Forebrain Development
Rna Interference
Secretion
Myoblast Migration
Limb Development

PTMs

Methylation

Cleavage

Glycosylation

Research Areas

Growth and Development
Neuronal Cell Markers
Neuroscience
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLIT1

References

PMID: 9813312 by Itoh A., et al. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.

PMID: 9693030 by Nakayama M., et al. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening.