SLCO3A1 Antibodies

AND SLCO3A1 ELISA kits, SLCO3A1 Proteins

Many biological assays use antibodies to detect SLCO3A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLCO3A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLCO3A1 antibodies...

We validate the specificity of these antibodies to SLCO3A1 by testing them on tissues known to express SLCO3A1 positively and negatively. Browse below to find the SLCO3A1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLCO3A1 Infographic by Boster Bio

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SLCO3A1 Overview

Facts about Solute carrier organic anion transporter family member 3A1.

SLCO3A1 3D structure. Source: alphafold

Solute carrier organic anion transporter family member 3A1 (SLCO3A1)

Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transportation of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3- sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).

Gene Information

Human
Gene Name:	SLCO3A1
Uniprot:	Q9UIG8
Entrez:	28232

Family

Belongs to:

organo anion transporter (TC 2.A.60) family

Alternative Names

FLJ40478; OATP3A1OATP-RP3; OATP-DOATPRP3; OATPDSLC21A11; Organic anion transporter polypeptide-related protein 3; Organic anion-transporting polypeptide D; PGE1 transporter; Sodium-independent organic anion transporter D; solute carrier family 21 (organic anion transporter), member 11; Solute carrier family 21 member 11; solute carrier organic anion transporter family member 3A1; solute carrier organic anion transporter family, member 3A1

Molecular Weight

Mass (kDA):
76.553 kDA

Genomic Context


Human

Location:	15q26.1
Sequence:	15; NC_000015.10 (91853708..92172435)

Tissue Specificity

Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Breast
Parkinson Disease
Liver Diseases
Burkitt Lymphoma
Infarction
Melanoma
Torsades De Pointes
Carcinoma
Immunologic Deficiency Syndromes
Myocardial Infarction
Neoplasms

Mammary Neoplasms
Tobacco Use Disorder
Dysequilibrium Syndrome
Lung Neoplasms
Long Qt Syndrome
Schizophrenia
Malignant Paraganglionic Neoplasm

Pathways

Transport
Localization
Excretion
Cell Proliferation
Response To Iloperidone
Mrna Transcription
Pathogenesis
Cardiac Conduction

Intestinal Absorption
Oligopeptide Transport

PTMs

Carboxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLCO3A1

References

PMID: 10873595 by Tamai I., et al. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.

PMID: 16971491 by Huber R.D., et al. Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain.