SLCO1B1 Antibodies

AND SLCO1B1 ELISA kits, SLCO1B1 Proteins

Many biological assays use antibodies to detect SLCO1B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLCO1B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLCO1B1 antibodies...

We validate the specificity of these antibodies to SLCO1B1 by testing them on tissues known to express SLCO1B1 positively and negatively. Browse below to find the SLCO1B1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLCO1B1 Infographic by Boster Bio

All SLCO1B1 Products

Product

Figures

Specificity

Applications

Price

Anti-SLCO1B1/Oatp2 Antibody

7 Q&As

Human

$360
Cat # A01375
100 µl

Anti-SLCO1B1 Antibody

Human

ELISA, IF, ICC, WB

$449
Cat # A01375-1
0.1 mg

SLCO1B1 Overview

Facts about Solute carrier organic anion transporter family member 1B1.

SLCO1B1 3D structure. Source: alphafold

Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions in the liver.

Gene Information

Human
Gene Name:	SLCO1B1
Uniprot:	Q9Y6L6
Entrez:	10599

Family

Belongs to:

organo anion transporter (TC 2.A.60) family

Alternative Names

HBLRR; LST1; LST-1; LST-2; LST3; LST-3TM13; OATP1B1; OATP1B3; OATP2; OATP8; OATP-8; OATPC; OATP-C; SLC21A6; SLC21A8; SLCO1B1 solute carrier organic anion transporter family, member 1B1

Molecular Weight

Mass (kDA):
76.449 kDA

Genomic Context


Human

Location:	12p12.1
Sequence:	12; NC_000012.12 (21131194..21239796)

Tissue Specificity

Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.

Subcellular Localizations

Basolateral cell membrane; Multi-pass membrane protein. Detected in basolateral membranes of hepatocytes.

Diseases

Myopathy
Malignant Neoplasms
Malignant Neoplasm Of Breast
Hypercholesterolemia
Neoplasms
Hiv Infections
Cholangiocarcinoma
Cardiovascular Diseases
Hyperbilirubinemia
Rhabdomyolysis
Diabetes Mellitus
Medication Reaction
Hypertensive Disease

Drug-induced Liver Injury
Diarrhea
Leukemia
Dysequilibrium Syndrome
Myalgia
Hyperbilirubinemia, Neonatal
Injury To Liver

Pathways

Transport
Excretion
Drug Transport
Response To Statin
Localization
Cell Death
Gallstone Formation
Organic Anion Transport
Intestinal Absorption
Translation
Anion Transport
Pathogenesis
Cholesterol Homeostasis

Secretion
Hypersensitivity
Sulfate Transport
Glucose Homeostasis
Drug Export
Xenobiotic Transport
Regulation Of Blood Pressure

PTMs

Phosphorylation

Carboxylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLCO1B1

References

PMID: 10358072 by Abe T., et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1.

PMID: 10601278 by Hsiang B.H., et al. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl- CoA reductase inhibitor transporters.