This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Na(+)/H(+) exchange regulatory cofactor NHE-RF1.
Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May improve Wnt signaling.
Human | |
---|---|
Gene Name: | SLC9A3R1 |
Uniprot: | O14745 |
Entrez: | 9368 |
Belongs to: |
---|
No superfamily |
EBP50NHERF-1; ezrin-radixin-moesin binding phosphoprotein-50; Ezrin-radixin-moesin-binding phosphoprotein 50; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na+/H+ exchange regulatory co-factor; NHERF1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1; NHERFNPHLOP2; Regulatory cofactor of Na(+)/H(+) exchanger; sodium/hydrogen exchanger regulatory factor 1; Sodium-hydrogen exchanger regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatoryfactor 1; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; Solute car
Mass (kDA):
38.868 kDA
Human | |
---|---|
Location: | 17q25.1 |
Sequence: | 17; NC_000017.11 (74748628..74769353) |
Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast.
Cytoplasm. Apical cell membrane. Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T-cells.
PMID: 9314537 by Reczek D., et al. Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family.
PMID: 9430655 by Murthy A., et al. NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins.