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- Table of Contents
Facts about Sodium/hydrogen exchanger 3.
Plays an essential role in signal transduction. .
Human | |
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Gene Name: | SLC9A3 |
Uniprot: | P48764 |
Entrez: | 6550 |
Belongs to: |
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monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family |
isoform 3; MGC126718; NHE3; NHE3MGC126720; SLC9A3; solute carrier family 9 (sodium/hydrogen exchanger), member 3; Solute carrier family 9 member 3
Mass (kDA):
92.855 kDA
Human | |
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Location: | 5p15.33 |
Sequence: | 5; NC_000005.10 (470456..524449, complement) |
Apical cell membrane; Multi-pass membrane protein. In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity).
PMID: 7631746 by Brant S.R., et al. Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3.
PMID: 19088451 by Zachos N.C., et al. Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.