SLC7A7 Antibodies

AND SLC7A7 ELISA kits, SLC7A7 Proteins

Many biological assays use antibodies to detect SLC7A7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC7A7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC7A7 antibodies...

We validate the specificity of these antibodies to SLC7A7 by testing them on tissues known to express SLC7A7 positively and negatively. Browse below to find the SLC7A7 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC7A7 Infographic by Boster Bio

All SLC7A7 Products

Product

Figures

Specificity

Applications

Price

SLC7A7 (NM_003982) Human Over-expression Lysate

Human

$628
Cat # LS009056
100 µg

Anti-SLC7A7 Antibody Picoband™

Human, Mouse, Rat

ELISA, IF, IHC, WB

$370
Cat # A03602-2
100 µg/vial

SLC7A7 Overview

Facts about Y+L amino acid transporter 1.

SLC7A7 3D structure. Source: alphafold

Y+L amino acid transporter 1 (SLC7A7)

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine.

Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes.

Gene Information

Human
Gene Name:	SLC7A7
Uniprot:	Q9UM01
Entrez:	9056

Family

Belongs to:

amino acid-polyamine-organocation (APC) superfamily

Alternative Names

LAT3; LPI; Monocyte amino acid permease 2; MOP-2; SLC7A7; solute carrier family 7 (cationic amino acid transporter, y+ system), member 7; Solute carrier family 7 member 7; Y+L amino acid transporter 1; Y+LAT1; y+LAT-1y(+)L-type amino acid transporter 1

Molecular Weight

Mass (kDA):
55.991 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (22773222..22819796, complement)

Tissue Specificity

Highest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, retinal pigment epithelial cells, and various carcinoma cell lines, with highest expression in a colon-carcinoma cell line.

Subcellular Localizations

Basolateral cell membrane; Multi-pass membrane protein.

Diseases

Lysinuric Protein Intolerance
Pulmonary Alveolar Proteinosis
Hyperammonemia
Aminoaciduria
Failure To Thrive
Osteoporosis
Kidney Diseases
Malignant Neoplasms
Lung Diseases
Neoplasms
Comatose

Cystinuria
Renal Aminoacidurias
Metabolic Acidosis
Dwarfism
Adenocarcinoma
Hereditary Diseases

Pathways

Transport
Amino Acid Transport
Arginine Transport
Pathogenesis
Urea Cycle
Excretion
Gene Silencing
Translation
Localization
Cell Activation
Osteoblast Differentiation
Immune Response
Leucine Transport

Intestinal Absorption
Myelination
Neutral Amino Acid Transport
Mast Cell Activation
Embryo Development
Inflammatory Response
Transepithelial Transport

PTMs

Carboxylation

Phosphorylation

Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC7A7

References

PMID: 9829974 by Torrents D., et al. Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance.

PMID: 9878049 by Pfeiffer R., et al. Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family.