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- Table of Contents
Facts about Solute carrier family 5 member 4.
Additionally potently activated by imino sugars like deoxynojirimycin (DNJ) (PubMed:17110502, PubMed:20421923, PubMed:22766068). .
Human | |
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Gene Name: | SLC5A4 |
Uniprot: | Q9NY91 |
Entrez: | 6527 |
Belongs to: |
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sodium:solute symporter (SSF) (TC 2.A.21) family |
DJ90G24.4; low affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 3; SAAT1; SAAT1low affinity sodium glucose cotransporter; SGLT2; SGLT3; SLC5A4; sodium transporter; Sodium/glucose cotransporter 3; solute carrier family 5 (low affinity glucose cotransporter), member 4; solute carrier family 5 (neutral amino acid transporters, system A), member 4; Solute carrier family 5 member 4
Mass (kDA):
72.456 kDA
Human | |
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Location: | 22q12.3 |
Sequence: | 22; NC_000022.11 (32218423..32355057, complement) |
Expressed in skeletal muscle, where it may localize to the neuromuscular junction (at protein level) (PubMed:13130073). Expressed in small intestine where it may localize to cholinergic neurons of the submucosal plexus and myenteric plexus (at protein level) (PubMed:13130073). Detected in kidney (at protein level) (PubMed:22766068).
Cell membrane; Multi-pass membrane protein.
PMID: 13130073 by Diez-Sampedro A., et al. A glucose sensor hiding in a family of transporters.
PMID: 17110502 by Voss A.A., et al. Imino sugars are potent agonists of the human glucose sensor SGLT3.