SLC4A8 Antibodies

AND SLC4A8 ELISA kits, SLC4A8 Proteins

Many biological assays use antibodies to detect SLC4A8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC4A8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC4A8 antibodies...

We validate the specificity of these antibodies to SLC4A8 by testing them on tissues known to express SLC4A8 positively and negatively. Browse below to find the SLC4A8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC4A8 Infographic by Boster Bio

All SLC4A8 Products

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Specificity

Applications

Price

Anti-SLC4A8 Antibody

Human, Mouse, Rat

$405
Cat # A08194
100ul

Anti-SLC4A8/10 Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A08194-1
100ul

SLC4A8 Overview

Facts about Electroneutral sodium bicarbonate exchanger 1.

SLC4A8 3D structure. Source: alphafold

Electroneutral sodium bicarbonate exchanger 1 (SLC4A8)

Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a significant role in pH regulation in neurons.

May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Increased expression in acute acid strain could be important for cell survival by mediating the influx of HCO3(-) into the cells.

Gene Information

Human
Gene Name:	SLC4A8
Uniprot:	Q2Y0W8
Entrez:	9498

Family

Belongs to:

anion exchanger (TC 2.A.31) family

Alternative Names

DKFZp761B2318; Electroneutral Na(+)-driven Cl-HCO3 exchanger; FLJ46462; KIAA0739; k-NBC3; Na+-driven Cl-HCO3 exchanger; NBC; NBC3electroneutral sodium bicarbonate exchanger 1; NDCBE; NDCBE1; Solute carrier family 4 member 8; solute carrier family 4, sodium bicarbonate cotransporter, member 8

Molecular Weight

Mass (kDA):
122.938 kDA

Genomic Context


Human

Location:	12q13.13
Sequence:	12; NC_000012.12 (51391317..51515763)

Tissue Specificity

Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Hypertensive Disease
Disease Of Adrenal Medulla
Acidosis
Brain Hypoxia
Neonatal Hypoxia
Columnar Cell Hyperplasia Of The Breast
Nervousness
Metabolic Acidosis

Hypoxia
Alkalosis

Pathways

Transport
Localization
Bicarbonate Transport
Renal Sodium Excretion
Prophase
Glycosylation
Metaphase
Meiotic Metaphase Ii

Intraflagellar Transport
Excretion

PTMs

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC4A8

References

PMID: 11133997 by Grichtchenko I.I., et al. Cloning, characterization, and chromosomal mapping of a human electroneutral Na(+)-driven Cl-HCO3 exchanger.

PMID: 10362779 by Amlal H., et al. Characterization of Na+/HCO-3 cotransporter isoform NBC-3.