SLC2A2 Antibodies

Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)

Facilitative glucose transporter. This isoform probably mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise a portion of the glucose-sensing mechanism of the beta cell.

May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the gut and kidney. .

Gene Information

Human
Gene Name:	SLC2A2
Uniprot:	P11168
Entrez:	6514

Family

Belongs to:
major facilitator superfamily

Alternative Names

GLUT2 Glucose transporter type 2, liver; Glut2; GLUT-2; SLC2A2; solute carrier family 2 (facilitated glucose transporter), member 2; solute carrier family 2, facilitated glucose transporter member 2

Molecular Weight

Mass (kDA):
57.49 kDA

Genomic Context

Human
Location:	3q26.2
Sequence:	3; NC_000003.12 (170996341..171026721, complement)

Tissue Specificity

Liver, insulin-producing beta cell, small intestine and kidney.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

• Diabetes Mellitus
• Diabetes Mellitus, Non-insulin-dependent
• Hyperglycemia
• Insulin Resistance
• Obesity
• Diabetes Mellitus, Experimental
• Impaired Glucose Tolerance
• Fanconi Syndrome
• Kidney Diseases
• Hypoglycemia
• Neoplasms
• Insulin Sensitivity

• Hepatomegaly
• Hyperinsulinism
• Diabetes Mellitus, Insulin-dependent
• Diabetic Nephropathy
• Malignant Neoplasms
• Carcinoma
• Inflammation

Pathways

• Secretion
• Transport
• Insulin Secretion
• Glucose Homeostasis
• Glucose Transport
• Cell Proliferation
• Pathogenesis
• Localization
• Lactation
• Cell Differentiation
• Regeneration
• Regulation Of Glucose Homeostasis
• Glycolysis

• Excretion
• Aging
• Intestinal Absorption
• Regulation Of Insulin Secretion
• Gluconeogenesis
• Cell Maturation
• Exocytosis

PTMs

• Phosphorylation
• Oxidation
• Glycosylation
• Nitration

• Nitrosylation
• Reduction
• Methylation
• Ubiquitination

Research Areas

• Lipid and Metabolism
• Stem Cell Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC2A2

Boster Bio - The Best Uses Of The SLC2A2 Marker

This article will review the SLC2A2 marker, its application for research, differences with other markers and the places it can be found. In addition, we'll go over how you can use it for reference. This information is applicable to all scientists, no matter where they are located. Read on for more details! Here are just some of the most effective uses for the marker SLC2A2.

Benefits of using the SLC2A2 Marker

In the past decade researchers have discovered that the SLC2A2 Marker may be a helpful tool in the treatment of certain cancers. Although this biomarker is under investigation, scientists have identified its potential role in the field of tumor immunology and the development of effective GC treatments. Its presence in tumors that are resistant to antiangiogenic therapies could indicate that it plays an important role in the field of cancer immunology.

Several studies have shown that various studies have proven that SLC2A2 Marker can increase the number of macrophages M2 in a tumor. Furthermore, the marker has been shown to be associated with multiple glucose transporter isozymes and phosphofructokinases. In addition, it was demonstrated that SLC2A3 can be involved in GC glycolysis in reprogramming.

Research applications in research

Applied research, as its name suggests, is science and research that has practical applications. The results of applied research are usually limited to a specific field and not intended to be generalized. However, the findings of applied research help organisations to find solutions that are practical and improve productivity and output. The primary difference between pure and applied research lies in the reason and method of applying these results. It is important to know the various types of applied research in order to comprehend how it operates. Here are some examples.

Companies can apply research in the business world. It helps them improve and improve their offerings by comparing them against their competition. It also helps them understand their market share. Governments of almost every country have begun to use applications of research to aid in environmental protection. The results of these studies are used by various NGOs to better understand the current situation and predict possible disasters. There are many other examples of how applied research has helped businesses, and isn't only limited to scientific fields.

Another significant aspect of ICT is its capacity to link databases. This allows the researchers to access information in a common format. It also assists researchers in data analysis prior to analysis, literature search content search, data collection, data analysis, plagiarism detection, manuscript submission and more. Apart from these benefits, the use of ICT in research has also boosted knowledge sharing within the research community. It is important to remember that research conducted using these technologies is not free.

Available

SLC2A2-related markers can be observed in cancer cells. This could be a sign of the presence or absence of p53, the disease-causing protein. This enzyme is responsible for CRC by regulating EMT, and immune responses. It may also influence EMT and PD-1-mediated immune responses. However, despite its role in CRC, it is unclear what the role of SLC2A3 in the disease.

SLC2A2 can be found in over 80% of human cancer cells. It is present in the brain, liver as well as the lungs, and has been associated with a poor prognosis among patients with gliomas. Although the role of SLC2A3 for cancer is still unclear however, it has been implicated in the metastasis of breast cancer cells. More research is required to determine the role of SLC2A2 for CRC.

SLC2A3 is a member in the family of SLC2A2A. It has been associated with low rates of survival free of disease and lymph node metastasis. Furthermore, SLC2A3 can activate YAP protein which is a major transcription factor in CRC. Additionally that high levels of SLC2A3 in CRC are associated with poor prognosis. In addition, it indicates aggressive behavior of CRC cells and the possibility of distant metastasis and MSI-H.

SLC2A3 regulates the progression of tumors and also influences the immune response. Its high expression is linked with inflammatory responses and interferon-g response pathways, including the IL6/JAK/STAT3 signaling pathway and CXCL9/STAT3 signals. This link between SLC2A3 and PD-L1 may also suggest that SLC2A3 could be a possible treatment target for immune-therapy.