Bile acyl-CoA synthetase Antibodies

Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the initial step in the conjugation of C24 bile acids (choloneates) into glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters.

Seems to trigger secondary bile acids entering the liver in the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving in the de novo synthesis from cholesterol.