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- Table of Contents
Facts about Pendrin.
Human | |
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Gene Name: | SLC26A4 |
Uniprot: | O43511 |
Entrez: | 5172 |
Belongs to: |
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SLC26A/SulP transporter (TC 2.A.53) family |
DFNB4; EVA; PDSTDH2B; pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4; solute carrier family 26, member 4
Mass (kDA):
85.723 kDA
Human | |
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Location: | 7q22.3 |
Sequence: | 7; NC_000007.14 (107660828..107717809) |
High expression in adult thyroid, lower expression in adult and fetal kidney and fetal brain. Not expressed in other tissues.
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney.
PMID: 9398842 by Everett L.A., et al. Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS).
PMID: 10192399 by Scott D.A., et al. The Pendred syndrome gene encodes a chloride-iodide transport protein.