Solute carrier family 22 member 17 (SLC22A17)

Cell surface receptor for LCN2 (24p3) that plays an integral role in iron homeostasis and transportation. Willing to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and resulting in inhibition of apoptosis.

Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, resulting in iron chelation and iron transfer into the extracellular medium, thereby reducing intracellular iron concentration and leading to apoptosis (By similarity). .