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- Table of Contents
Facts about Excitatory amino acid transporter 4.
Mediates Cl(-) flux that's not coupled to amino acid transport; this avoids the accumulation of negative charges because of aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is vital for terminating the postsynaptic action of glutamate (Probable).
Human | |
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Gene Name: | SLC1A6 |
Uniprot: | P48664 |
Entrez: | 6511 |
Belongs to: |
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dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family |
EAAT4MGC43671; excitatory amino acid transporter 4; MGC33092; Sodium-dependent glutamate/aspartate transporter; solute carrier family 1 (high affinity aspartate/glutamate transporter), member6; Solute carrier family 1 member 6
Mass (kDA):
61.565 kDA
Human | |
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Location: | 19p13.12 |
Sequence: | 19; NC_000019.10 (14950033..15010643, complement) |
Brain. Expressed densely and selectively in cell bodies of Purkinje cells.
Cell membrane; Multi-pass membrane protein.
PMID: 7791878 by Fairman W.A., et al. An excitatory amino-acid transporter with properties of a ligand- gated chloride channel.