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- Table of Contents
1 Citations 6 Q&As
Facts about Excitatory amino acid transporter 1.
Mediates Cl(-) flux that's not coupled to amino acid transport; this avoids the accumulation of negative charges because of aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is vital for terminating the postsynaptic action of glutamate (By similarity).
Human | |
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Gene Name: | SLC1A3 |
Uniprot: | P43003 |
Entrez: | 6507 |
Belongs to: |
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dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family |
EA6; EA6FLJ25094; EAAT1; EAAT1GLAST-1; excitatory amino acid transporter 1; GLAST; GLAST1; GLAST-1; GLASTGLAST1; SLC1A3; Sodium-dependent glutamate/aspartate transporter 1; solute carrier family 1 (glial high affinity glutamate transporter), member 3; Solute carrier family 1 member 3
Mass (kDA):
59.572 kDA
Human | |
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Location: | 5p13.2 |
Sequence: | 5; NC_000005.10 (36606355..36688334) |
Detected in brain (PubMed:8218410, PubMed:7521911, PubMed:8123008). Detected at very much lower levels in heart, lung, placenta and skeletal muscle (PubMed:7521911, PubMed:8123008). Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia (PubMed:7521911).
Cell membrane; Multi-pass membrane protein.
PMID: 8218410 by Shashidharan P., et al. Cloning and characterization of a glutamate transporter cDNA from human cerebellum.
PMID: 7521911 by Arriza J.L., et al. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.
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