SLC19A1 Antibodies

Reduced folate transporter (SLC19A1)

Transporter for the intake of folate.

Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump.

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Gene Information

Human
Gene Name:	SLC19A1
Uniprot:	P41440
Entrez:	6573

Family

Belongs to:
reduced folate carrier (RFC) transporter (TC 2.A.48) family

Alternative Names

CHMD; FLOT1; folate transporter 1; FOLT; FOLThuman reduced folate carrier (RFC)10Intestinal folate carrier 1; IFC1; IFC-1; Placental folate transporter; Reduced folate carrier protein; REFC; RFC; RFC1; SLC19A1; solute carrier family 19 (folate transporter), member 1; Solute carrier family 19 member 1

Molecular Weight

Mass (kDA):
64.868 kDA

Genomic Context

Human
Location:	21q22.3
Sequence:	21; NC_000021.9 (45502517..45563140, complement)

Tissue Specificity

Placenta, liver, and to a much smaller extent, in lung.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.

Diseases

• Malignant Neoplasms
• 5,10-methylenetetrahydrofolate Reductase Deficiency
• Leukemia
• Neoplasms
• Folic Acid Deficiency
• Acute Lymphocytic Leukemia
• L1 Acute Lymphoblastic Leukemia
• Leukemia L1210
• Arthritis
• Malignant Neoplasm Of Breast
• Rheumatoid Arthritis
• Osteosarcoma
• Down Syndrome

• Lung Neoplasms
• Congenital Abnormality
• Lymphoma
• Leukemia, T-cell
• Myeloproliferative Syndrome, Transient
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Lung

Pathways

• Transport
• Methylation
• Methotrexate Transport
• Localization
• Translation
• Drug Resistance
• Response To Methotrexate
• Dna Methylation
• Pathogenesis
• Drug Transport
• Cell Proliferation
• Anion Transport
• Gene Silencing

• Intestinal Absorption
• Cell Division
• Cell Cycle
• Chromosome Breakage
• Thiamine Transport
• Glycosylation
• Dna Repair

PTMs

• Methylation
• Demethylation
• Reduction
• Glycosylation
• Acetylation

• Deglycosylation
• Phosphorylation
• Carboxylation
• Biotinylation
• Deacetylation

• Gamma-carboxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC19A1

Boster Bio - Best Uses Of The SLC19A1 Marker

In this article, we'll examine the background of Steven Boster and the anti-RFC/SLC19A1 marker. We will also discuss the advantages of this marker, such as its high-affinity primary antibody. We'll also discuss the ways Boster scientists can benefit from this marker. Boster's product credits are used by scientists around the world.

Boster Bio's gene infographics

For researchers and scientists working in the molecular biology field, Boster Bio's SLC19A1, also known as the SLC19A1 marker gene, infographics can help users visualize the data gathered from their research. Boster scientists can utilize the SLC19A1 gene infographics to submit their results to specific companies or agencies, and to receive product credits for their work. The infographics are arranged based on the location of the gene that it is associated with, as well as the subcellular location.

The history of Steven Boster

Steven Boster created his first product in 1993. He earned the name "He who transforms science in the lavatory," and went on to develop hundreds of primary antibodies and various products for IHC. Steven Boster was developing proprietary ELISA platforms and had also founded a Chinese-based catalog antibody business. These platforms are built on proprietary trade secrets that provide high-sensitivity ELISA kit kits.

Boster's high-affinity , primary antibodies

The marker SLC19A1 helps capture the CDNs as well as other molecules in cells. In mice cells SLC19A1 inhibition didn't reduce CDN uptake. In humans, SLC19A1 is essential for the uptake of CDNs which can have implications for immunotherapy and a variety of inflammation-related diseases. Boster's high-affinity primary antibodies use this marker to recognize and identify these molecules.

The SLC19A1 antibody made by Boster Bio is part of the Picoband(tm) catalog. It reacts with Human, Mouse, Rat and Monkey. The antibody is extremely specific for the marker SLC19A1 and is well-suited for multiple immunoblotting techniques. It is available in several concentrations and is highly compatible with other primary antibodies with high affinity.

SLC19A1 is required for CDN uptake by metazoan cells. This protein is essential for CDN uptake in human cells as well as primary tumor tissues and human cell lines. In addition, methotrexate an anti-folate medication, blocks SLC19A1 expression. However, it does not hinder the uptake of 2'3'-cGAMP in murine lymphoid cells.

SLC19A1 is required for CDN transport. Different cell lines were transduced with SLC19A1 expression vectors, or non-targeting control gene gRNA. Transduced cells with shRNA from SLC19A1 or hIFN-b were analyzed to determine the response to CDNs. A representative flow plot is shown in Extended Data Figure. 3j.

Boster's high-affinity prima antibodies utilize the SLC19A1 marker to attach to the SLC19A1 protein. The marker SLC19A1 can be employed in a variety of ways. It is highly specific and is tolerant of minor changes in antigen. It can also be employed in diagnostic tests for cancer treatment and diagnosis. However secondary antibodies are required for indirect detection.

Traditional chromogenic mIHC relies on different types and species of the same protein. To increase the amplification of these antibodies are often used together with secondary antibodies. To ensure a more exact outcome, make sure you use a nonoverlapping background control in addition to the capture and detection antibodies. Using the same antibody for capture and detection may limit the their dynamic range and sensitivity.

Boster's anti-RFC/SLC19A1 marker

The Boster bio Anti-RFC/SLC19A1 marker can be obtained via Picoband(tm). This antibody binds to Human and reacts with it. It can be stored at -20°C for a year, or at 4°C for up to one month. The antibody contains Trehalose as a carrier and NaCl and Na2HPO4 as buffers. The following ingredients are in each vial: