SLC15A2 Antibodies

Solute carrier family 15 member 2 (SLC15A2)

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity).

Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity). .

Gene Information

Human
Gene Name:	SLC15A2
Uniprot:	Q16348
Entrez:	6565

Family

Belongs to:
PTR2/POT transporter (TC 2.A.17) family

Alternative Names

Kidney H(+)/peptide cotransporter; kidney isoform; PEPT2; PEPT2FLJ33407; Peptide transporter 2; SLC15A2; solute carrier family 15 (H+/peptide transporter), member 2; solute carrier family 15 member 2

Molecular Weight

Mass (kDA):
81.783 kDA

Genomic Context

Human
Location:	3q13.33
Sequence:	3; NC_000003.12 (121894401..121944188)

Tissue Specificity

Expressed in kidney. Not detected in intestine.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

• Brain Death
• Liver Diseases
• Nerve Degeneration
• Neurotoxicity Syndromes
• Tissue Adhesions
• Disorders Of Porphyrin Metabolism
• Porphyrias, Hepatic
• Contagious Equine Metritis
• Meningitis
• Neoplasms
• Hiv Infections

• Liver Neoplasms
• Alzheimer's Disease
• Poisoning
• Lead Poisoning
• Dysequilibrium Syndrome
• Meningitis, Bacterial

Pathways

• Transport
• Dna Methylation
• Methylation
• Transepithelial Transport
• Peptide Transport
• Proteolysis
• Inner Ear Development
• Histone Modification
• Localization
• Intestinal Absorption

• Drug Transport
• Ear Development
• Mrna Processing
• Pathogenesis
• Excretion

PTMs

• Acetylation

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC15A2

Best Uses Of The SLC15A2 Marker

You have come to the right spot if you're looking high-affinity primary antibody for research. Boster has high-affinity antibodies that have been extensively validated for use in Western Blotting, Immunohistochemistry, and ELISA. Boster Bio, a world-renowned biotech company, has these antibodies. They are available from Boster Bio.

Primary antibodies with high-affinity

Scientists used phage display to identify peptides with high affinity. This technique involves immobilizing the antigen on magnetic beads, and then selecting antibodies that recognize the peptide. These antibodies were then purified, and characterized using affinity chromatography. The recombinant Fabs used to generate the antibodies were generated using RapMAT technology, HuCAL PLATINUM library, and bovine serum albumin conjugates.

Numerous studies have shown the utility of this technique in producing high-affinity prima antibodies. It is a useful technique for screening and identifying proteins which are difficult to detect by traditional methods. The SLC15A2 marker is used to identify monoclonal antigens with high-specific and tolerant antigens. For this research, a mouse was used as a model.

These studies have shown that SLC15A2 is linked with cancer. The SLC15A2 mark is an important determinant for the detection of cancer cells. The SLC15A2 marker can be used to detect cancer cells because the protein shares 20 percent amino acids homology with SLC15A1. This marker provides new insights into cancer cells' biological functions. It is also useful for developing therapeutic antibodies.

The lung cancer-causing protein SLC15A2 has been studied. Data from a lung database was used in a study published by Oncomine. SLC15A2 expression appeared to be the same in lung adenocarcinoma as squamous cellular carcinoma cells. SLC15A4 was more prominent in squamous cellular carcinoma. There was also a significant difference between normal and tumor tissue in different patients.

Career

SLC15A2 markers can lead to a variety in biomedical research. The gene is expressed at a high level by lung cancer cells. It has potential clinical applications and prognostic value. However, it remains largely unknown as to its exact function and role in cancer. Therefore, further studies are needed to investigate its functional role. Although the gene is still being studied, it has been linked to lung cancer.

The RNA-seq data of SLC15A2 were retrieved from the TCGA, GTEx lung cancer databases. They were then analyzed using Kaplan Meier plotter. This plotter provides information on 54k genes, and their expression in 21 kinds of cancer. To evaluate the overall survival rate for lung cancer patients in different types of subtypes, the median signal intensity of SLC15A2 were used. The log-rank P-values were used to determine statistical significance. SLC15A2 has also been selected as a downstream genes in molecular pathway analysis.

Research

The SLC15A2 gene, which is found in both normal and cancerous tissues, is associated with poor prognosis. SLC15A2 is associated not only with poor prognosis but also with high rates DNA mutation in cancer cells. A Kaplan-Meier plotter was used to evaluate the gene's expression in lung cancer patients. This plot can evaluate the survival effects of 54k genes across 21 types cancers. The median signal expression was used to evaluate the effect of SLC15A2 gene transcription on overall survival in patients with lung cancer. Log-rank P values were used to determine statistical significance.

SLC15A4 is highly expressed within cancer cells. SLC15A4 gene expression was also elevated in most colorectal and other types of cancers. Its expression may identify initial CRC cells, but its role in ovarian cancer and prostate cancer chemotherapy remains unclear. Its expression levels may vary from one region to the next. The SLC15A2 marker could be used to identify cancer cells.

The SLC15A2 family is made up of the PTR2/POT transporter families. It may be a crucial factor in opioid neurotransmission. The gene is not approved for use in clinical diagnosis or prognostication. However, it could be of clinical benefit. It is also a biomarker for many types of cancers. Order Primary Antibodies for SLC15A2 today from us. Our primary antibodies have a one year guarantee

SLC15A2 gene is also linked to cancer. Its expression levels have been found to be similar in three cell types. SLC15A2 gene has a higher rate of cancer cell growth than SLC15A1. This gene is also found on cancer cells. Hence, research with SLC15A2 gene has a great potential in the treatment of cancer. This gene is closely related to SLC1B.