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- Table of Contents
Facts about Natural resistance-associated macrophage protein 2.
Involved in apical iron uptake into duodenal enterocytes. Involved in iron transfer from acidified endosomes into the cytoplasm of erythroid precursor cells.
Human | |
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Gene Name: | SLC11A2 |
Uniprot: | P49281 |
Entrez: | 4891 |
Belongs to: |
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NRAMP family |
DCT1; DCT1NRAMP 2; Divalent cation transporter 1; Divalent metal transporter 1; DMT-1; DMT1FLJ37416; member 2; NRAMP2; NRAMP2natural resistance-associated macrophage protein 2; SLC11A2; solute carrier family 11 (proton-coupled divalent metal ion transporters)
Mass (kDA):
62.266 kDA
Human | |
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Location: | 12q13.12 |
Sequence: | 12; NC_000012.12 (50952263..51028335, complement) |
Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney.
[Isoform 2]: Cell membrane; Multi-pass membrane protein. Early endosome.; Endosome membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Also found in extracellular vesicles different from exosomes.
PMID: 9464519 by Kishi F., et al. Complete nucleotide sequence of human NRAMP2 cDNA.
PMID: 9790986 by Kishi F., et al. Human natural resistance-associated macrophage protein 2: gene cloning and protein identification.