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- Table of Contents
Facts about Signaling lymphocytic activation molecule.
Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP or SH2D1B/EAT-2. SLAMF1-induced signal- transduction events in T-lymphocytes are different from those in B-cells.
Human | |
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Gene Name: | SLAMF1 |
Uniprot: | Q13291 |
Entrez: | 6504 |
Belongs to: |
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No superfamily |
CD 150; CD150; CD150IPO-3; CDw150; IPO-3; signaling lymphocytic activation molecule family member 1; signaling lymphocytic activation molecule; SLAM; SLAMCD150 antigen; SLAMF1
Mass (kDA):
37.231 kDA
Human | |
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Location: | 1q23.3 |
Sequence: | 1; NC_000001.11 (160608100..160647311, complement) |
Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation (PubMed:7617038). Activated B-cells express isoform 1, isoform 3 and a cytoplasmic isoform (PubMed:9091591). Isoform 4 is expressed in B-cells, primary T-cells, dendritic cells and macrophages. Isoform 4 is expressed in tumors of the central nervous system (PubMed:25710480).
Cell membrane; Single-pass type I membrane protein. Present on the surface of B-cells and T-cells. Located at the plasma membrane contacts between neighboring T-cells (PubMed:11806999).; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane. Overexpressed isoform 4 is detected on the cell surface. In glioma cell lines endogenuous isoform 4 is detetced predominantly in the cytoplasm and colocalized with endoplasmic reticulum and Golgi markers.
PMID: 7617038 by Cocks B.G., et al. A novel receptor involved in T-cell activation.
PMID: 25710480 by Romanets-Korbut O., et al. Expression of CD150 in tumors of the central nervous system: identification of a novel isoform.