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SIRT3 Antibodies
AND SIRT3 ELISA kits, SIRT3 Proteins
Many biological assays use antibodies to detect SIRT3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIRT3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIRT3 antibodies...
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SIRT3 Overview
Facts about NAD-dependent protein deacetylase sirtuin-3, mitochondrial.
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)
NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340).
Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090).Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090).
Gene Information
| Human | |
|---|---|
| Gene Name: | SIRT3 |
| Uniprot: | Q9NTG7 |
| Entrez: | 23410 |
Family
| Belongs to: |
|---|
| sirtuin family |
Alternative Names
EC 3.5.1; EC 3.5.1.-; hSIRT3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase; NAD-dependent deacetylase sirtuin-3, mitochondrial; SIR2L3; SIR2L3silent mating type information regulation 2, S.cerevisiae, homolog 3; sir2-like 3; SIR2-like protein 3; SIRT3; sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; Sirtuin 3; sirtuin type 3
Molecular Weight
Mass (kDA):
43.573 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.5 |
| Sequence: | 11; NC_000011.10 (215030..236931, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Mitochondrion matrix.
Diseases
- Malignant Neoplasms
- Neoplasms
- Diabetes Mellitus
- Obesity
- Metabolic Diseases
- Hypertrophy
- Cell Transformation, Neoplastic
- Cardiac Hypertrophy
- Insulin Resistance
- Inflammation
- Neurodegenerative Disorders
- Liver Diseases
Interacting Proteins
- ATP5F1A
- OPA1
- SKP2
Pathways
- Aging
- Protein Acetylation
- Localization
- Cell Death
- Protein Deacetylation
- Cell Growth
- Fatty Acid Oxidation
- Pathogenesis
- Transport
- Electron Transport
- Electron Transport Chain
- Cell Cycle
- Glycolysis
PTMs
- Deacetylation
- Acetylation
- Oxidation
- Phosphorylation
- Cleavage
- Ubiquitination
Research Areas
- Epigenetics
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIRT3
bosterbio.com/bosterbio-gene-info-cards/SIRT3
References
PMID: 10381378 by Frye R.A.; Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
PMID: 12186850 by Schwer B., et al. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase.
2 Publications of Boster SIRT3 Antibodies & ELISA Kits
- PubMed ID: 10.3892/ijmm.2019.4173, Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and ...
- PubMed ID: 10.1016/j.numecd.2021.01.006, Moderate Offspring Exercise offsets Harmful Effects of the Maternal Protein Depr...
*More publications can be found for each product on its corresponding product page