SIGLEC8 Antibodies

AND SIGLEC8 ELISA kits, SIGLEC8 Proteins

Many biological assays use antibodies to detect SIGLEC8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIGLEC8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIGLEC8 antibodies...

We validate the specificity of these antibodies to SIGLEC8 by testing them on tissues known to express SIGLEC8 positively and negatively. Browse below to find the SIGLEC8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SIGLEC8 Infographic by Boster Bio

All SIGLEC8 Products

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Product

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Specificity

Applications

Price

Anti-SIGLEC8 Antibody

Human, Mouse, Rat

$405
Cat # A09153
100ul

SIGLEC8 (NM_014442) Human Over-expression Lysate

Human

$628
Cat # LS027181
100 µg

SIGLEC8 Overview

Facts about Sialic acid-binding Ig-like lectin 8.

SIGLEC8 3D structure. Source: alphafold

Sialic acid-binding Ig-like lectin 8 (SIGLEC8)

Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619). Preferentially binds to alpha-2,3-linked sialic acid.

Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619).

Gene Information

Human
Gene Name:	SIGLEC8
Uniprot:	Q9NYZ4
Entrez:	27181

Family

Belongs to:

immunoglobulin superfamily

Alternative Names

CD329 antigen; CDw329; MGC59785; SAF2; SAF2SAF-2; sialic acid binding Ig-like lectin 8; Sialoadhesin family member 2; Siglec8; Siglec-8; SIGLEC8L; SIGLEC8Lsialic acid-binding Ig-like lectin 8

Molecular Weight

Mass (kDA):
54.042 kDA

Genomic Context


Human

Location:	19q13.41
Sequence:	19; NC_000019.10 (51450997..51458454, complement)

Tissue Specificity

Expressed specifically on red blood cells namely basophil, mast cells and eosinophils.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Inflammation
Asthma
Eosinophilia
Tissue Adhesions
Hypereosinophilic Syndrome
Allergy
Autoimmune Reaction
Rhinorrhea
Myeloid Leukemia, Chronic
Immediate Hypersensitivity
Churg-strauss Syndrome
Eosinophilic Leukemia
Mucocutaneous Lymph Node Syndrome

Delayed Hypersensitivity
Malignant Neoplasms
Myeloid Leukemia
Esophagitis
Lupus Erythematosus, Systemic
Chimera Disorder
Tissue Damage

Interacting Proteins

TFF1

Pathways

Cell Death
Transport
Electron Transport
Pathogenesis
Smooth Muscle Contraction
Programmed Cell Death
Induction Of Apoptosis
Anaphylaxis
Glycosylation
Hypersensitivity
Muscle Contraction

Chemotaxis
Sensitization
Mrna Splicing
Mast Cell Degranulation
Secretion

PTMs

Cleavage
Sulphation

Biotinylation
Reduction

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIGLEC8

References

PMID: 11095983 by Foussias G., et al. Molecular characterization of a siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the siglec8 gene.

PMID: 10856141 by Kikly K.K., et al. Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils.