SIAH1 Antibodies

E3 ubiquitin-protein ligase SIAH1 (SIAH1)

E3 ubiquitin ligases take ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes.

Triggers the ubiquitin-mediated degradation of several substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation.

Gene Information

Human
Gene Name:	SIAH1
Uniprot:	Q8IUQ4
Entrez:	6477

Family

Belongs to:
SINA (Seven in absentia) family

Alternative Names

E3 ubiquitin-protein ligase SIAH1; EC 6.3.2; EC 6.3.2.-; FLJ08065; hSIAH1; HUMSIAH; seven in absentia homolog 1 (Drosophila); Seven in absentia homolog 1; Siah-1; SIAH1A; siah-1a

Molecular Weight

Mass (kDA):
31.123 kDA

Genomic Context

Human
Location:	16q12.1
Sequence:	16; NC_000016.10 (48354581..48448435, complement)

Tissue Specificity

Widely expressed at a low level. Down- regulated in advanced hepatocellular carcinomas.

Subcellular Localizations

Cytoplasm. Nucleus. Predominantly cytoplasmic. Partially nuclear.

Diseases

• Neoplasms
• Malignant Neoplasms
• Cell Transformation, Neoplastic
• Carcinoma
• Mammary Neoplasms
• Liver Carcinoma
• Liver Neoplasms
• Leukemia
• Malignant Neoplasm Of Breast
• Hypoxia
• Carcinogenesis
• Parkinson Disease
• Malignant Paraganglionic Neoplasm

• Chromosomal Translocation
• Cell Invasion
• Brain Ischemia
• Malignant Tumor Of Colon
• Neoplasm Invasiveness
• Lymphoma
• Epstein-barr Virus Infections

Pathways

• Cell Death
• Localization
• Cell Cycle
• Senescence
• Cell Migration
• Programmed Cell Death
• Cellular Senescence
• Cell Proliferation
• Cell Growth
• Glycolysis
• Aging
• Lung Development
• Protein Nitrosylation

• Cell Cycle Arrest
• Embryo Development
• Cell Division
• Replicative Senescence
• Reverse Transcription
• Sensitization
• Translation

PTMs

• Ubiquitination
• Phosphorylation
• Nitrosylation
• Cleavage
• Hydroxylation

• Acetylation
• Biotinylation
• Reduction
• Glycosylation
• Deacetylation

• Methylation

Research Areas

• Apoptosis
• Cancer
• Cell Cycle and Replication
• Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIAH1

Best Uses Of The SIAh2 Marker

This article will explain how Boster Bio's anti KHDRBS22 antibody works. It also covers the benefits and uses of its anti-Bax S4 (S4) antibody. We'll discuss which applications these antibodies are most useful for. We'll also discuss how to use them in your experiments. So, let's get started.

Boster Bio has developed an anti-KHDRBS2 antibody

A great way to identify the protein of concern is to use the SIAh2 mark. This Boster Bio antibody (catalog number A02095) is highly specific for humans, mice, and rats. The antibody is also a good choice to use in ELISA tests. Boster offers a variety of high-affinity primary antibodies that are widely cited in the scientific literature and trusted by scientists worldwide.

Anti-KHDRBS2 antibody

The antibodies that are used to detect Khdrbs2 are either monoclonal or polyclonal in nature, and they react with Khdrbs2 in a variety of animal samples. Boster Bio sources its Khdrbs2 antibodies from both rabbit and mouse. This protein is a KH domain-containing RNA-binding signal transduction-associated protein that regulates alternative splicing and mRNA translation. It also influences mRNA transcription by binding to the exonic enhancementr, which affects exon incorporation in premRNAs.

Anti-Bax S4 antibody

The Boster Bio Anti-Bax (Picoband) antibody is tested in IP, WB, and IHC. It reacts with Human. The antibody comes as 100ul in liquid form. The price of the blocking peptide depends on the length of the immunogen. We'll be discussing both the BosterBio Anti-Bax(Picoband) as well as the BosterBio Anti-Bax(S4) antibodies in this article.

The Boster Bio Anti-Bax (Picobond) Monoclonal Antibody recognizes the N-terminus of human BAX. The company has developed this antibody for multiple species and is committed in quality control. The company offers technical support and rigorous testing of all products. This antibody is particularly useful in detecting genes that have been genetically modified, such as p23. The Boster Bio Anti-Bax or Picobond antibody is an excellent choice, in addition to these benefits.