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SHB Antibodies
AND SHB ELISA kits, SHB Proteins
Many biological assays use antibodies to detect SHB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SHB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SHB antibodies...
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SHB Infographic by Boster Bio
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SHB Overview
Facts about SH2 domain-containing adapter protein B.
SH2 domain-containing adapter protein B (SHB)
Adapter protein that regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling.
May also play a part in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | SHB |
| Uniprot: | Q15464 |
| Entrez: | 6461 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
bA3J10.2; RP11-3J10.8; SH2 domain-containing adapter protein B; SHB (Src homology 2 domain containing) adaptor protein B; SHB adaptor protein (a Src homology 2 protein); SHB; Src homology 2 domain containing adaptor protein B
Molecular Weight
Mass (kDA):
55.042 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p13.1 |
| Sequence: | 9; NC_000009.12 (37915898..38069227, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Associates with membrane lipid rafts upon TCR stimulation.
Diseases
- Tumor Angiogenesis
- Neoplasms
- Malignant Neoplasms
- Tissue Adhesions
- Hiv Infections
- Hepatitis
- Carcinoma
- Diabetes Mellitus
- Vomiting
- Hepatitis B
- Immunologic Deficiency Syndromes
- Pathologic Neovascularization
Interacting Proteins
- ABL1
- KIT
- MET
Pathways
- Angiogenesis
- Cell Differentiation
- Cell Proliferation
- Secretion
- Cell Death
- Glucose Homeostasis
- Vesicle Fusion
- Cell Migration
- Stem Cell Differentiation
- Reflex
- Induction Of Apoptosis
- Insulin Secretion
- Membrane Fusion
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SHB
bosterbio.com/bosterbio-gene-info-cards/SHB
References
PMID: 8302579 by Welsh M., et al. Shb is a ubiquitously expressed Src homology 2 protein.
PMID: 7537362 by Karlsson T., et al. Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.