SHANK1 Antibodies

AND SHANK1 ELISA kits, SHANK1 Proteins

Many biological assays use antibodies to detect SHANK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SHANK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SHANK1 antibodies...

We validate the specificity of these antibodies to SHANK1 by testing them on tissues known to express SHANK1 positively and negatively. Browse below to find the SHANK1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SHANK1 Infographic by Boster Bio

All SHANK1 Products

Product

Figures

Specificity

Applications

Price

Anti-SHANK1a N-Terminus Antibody

Human, Mouse, Rat

$280
Cat # A05690
100 ug

SHANK1 Overview

Facts about SH3 and multiple ankyrin repeat domains protein 1.

SHANK1 3D structure. Source: alphafold

SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)

Appears like an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

Gene Information

Human
Gene Name:	SHANK1
Uniprot:	Q9Y566
Entrez:	50944

Family

Belongs to:

SHANK family

Alternative Names

SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; Shank1; Somatostatin receptor-interacting protein; SSTR-interacting protein; SSTRIPSPANK-1; synamon

Molecular Weight

Mass (kDA):
224.959 kDA

Genomic Context


Human

Location:	19q13.33
Sequence:	19; NC_000019.10 (50659255..50719802, complement)

Tissue Specificity

Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.

Subcellular Localizations

Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Colocalizes with alpha-latrotoxin receptor 1.

Diseases

Autistic Disorder
Alzheimer's Disease
Tissue Adhesions
Peripheral Nerve Injuries
Dementia
Sciatic Neuropathy
Pain
Memory Impairment
Nerve Damage
Schizophrenia
Hyperalgesia
Thermal Hyperalgesia

Impairment (finding)
Autism Spectrum Disorders
Amnesia
Malignant Neoplasm Of Liver
Myxoid Cyst
Memory Disorders

Interacting Proteins

RPS6KA2

Pathways

Localization
Synaptic Transmission
Cell Adhesion
Dendritic Spine Morphogenesis
Translation
Long-term Memory
Transport
Synapse Maturation
Brain Development
Defecation Rhythm
Dna Methylation
Endocytosis
Mrna Transport

Anaphase
Regulation Of Dendritic Spine Morphogenesis
Methylation
Mrna Splicing
Cell Cycle
Synapse Assembly
Regulation Of Translation

PTMs

Phosphorylation

Methylation

Ubiquitination

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SHANK1

References

PMID: 10551867 by Zitzer H., et al. Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain.

PMID: 10806096 by Sheng M., et al. The Shank family of scaffold proteins.