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SH3KBP1 Antibodies
AND SH3KBP1 ELISA kits, SH3KBP1 Proteins
Many biological assays use antibodies to detect SH3KBP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SH3KBP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SH3KBP1 antibodies...
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SH3KBP1 Infographic by Boster Bio
All SH3KBP1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A02835-1
100 μg/vial
Cat # A02835-1
100 μg/vial
SH3KBP1 Overview
Facts about SH3 domain-containing kinase-binding protein 1.
SH3 domain-containing kinase-binding protein 1 (SH3KBP1)
Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, such as EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and so the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2.
Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | SH3KBP1 |
| Uniprot: | Q96B97 |
| Entrez: | 30011 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
C-Cbl-Interacting Protein; CD2-binding protein 3; CD2BP3; CIN85; CIN85Cbl-interacting protein of 85 kDa; GIG10; HSB1; HSB-1; Human Src family kinase-binding protein 1; MIG18; migration-inducing gene 18; SH3 domain-containing kinase-binding protein 1; SH3-domain kinase binding protein 1; SH3KBP1; Src family kinase-binding protein 1; src-related kinase binding protein-1
Molecular Weight
Mass (kDA):
73.126 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp22.12 |
| Sequence: | X; NC_000023.11 (19533965..19887600, complement) |
Tissue Specificity
Ubiquitously expressed. Also expressed in some cancer cell lines.
Subcellular Localizations
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell junction, focal adhesion. Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes. Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (By similarity). Colocalizes with ZFP36 in the cytoplasm (PubMed:20221403).
Diseases
- Neoplasms
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasm Invasiveness
- Carcinoma
- Cell Invasion
- Mammary Neoplasms
- Cholangiocarcinoma
- Glioma
- Nephrotic Syndrome
- Neurodegenerative Disorders
- Nervousness
Interacting Proteins
- ARAP3
- ASAP1
- CAPZA1
- CBL
- CBLB
- CD2
- Dab2
- DDN
- DNM2
- Dnm2
Pathways
- Endocytosis
- Clathrin-mediated Endocytosis
- Localization
- Receptor Internalization
- Cell Death
- Transport
- Cell Adhesion
- Protein Phosphorylation
- Cell Activation
- Cellular Homeostasis
- Pathogenesis
- Viral Replication
- Rna Interference
PTMs
- Phosphorylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SH3KBP1
bosterbio.com/bosterbio-gene-info-cards/SH3KBP1
References
PMID: 10679202 by Take H., et al. Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl.
PMID: 12618476 by Tibaldi E.V., et al. CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment but elicit divergent functional activities.