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Endophilin-B1 Antibodies
AND SH3GLB1 ELISA kits, Endophilin-B1 Proteins
Many biological assays use antibodies to detect Endophilin-B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Endophilin-B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Endophilin-B1 antibodies...
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SH3GLB1 Overview
Facts about Endophilin-B1.
Endophilin-B1 (SH3GLB1)
May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity).
May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588).
Gene Information
| Human | |
|---|---|
| Gene Name: | SH3GLB1 |
| Uniprot: | Q9Y371 |
| Entrez: | 51100 |
Family
| Belongs to: |
|---|
| endophilin family |
Alternative Names
Bax-interacting factor 1; Bif1; Bif-1; Bif-1dJ612B15.2; CGI-61; Endophilin B1; endophilin-B1; KIAA0491endophilin B1; SH3 domain-containing GRB2-like protein B1; SH3-containing protein SH3GLB1; SH3-domain GRB2-like endophilin B1; SH3-domain, GRB2-like, endophilin B1; SH3GLB1
Molecular Weight
Mass (kDA):
40.796 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p22.3 |
| Sequence: | 1; NC_000001.11 (86704570..86748184) |
Tissue Specificity
Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes.
Subcellular Localizations
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane. Midbody. Association with the Golgi apparatus depends on the cell type (By similarity). Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes (PubMed:17891140).
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Carcinoma
- Adenocarcinoma
- Mammary Neoplasms
- Stomach Neoplasms
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Immunologic Deficiency Syndromes
- Colorectal Neoplasms
- Carcinogenesis
- Malignant Neoplasm Of Prostate
Interacting Proteins
- BAX
- CMTM5
- COQ8A
- FUNDC1
- GADD45A
- PSMA1
- SH3GLB2
- TFIP11
- UVRAG
- ZNF576
Pathways
- Autophagy
- Cell Death
- Endocytosis
- Programmed Cell Death
- Cellular Homeostasis
- Regulation Of Autophagy
- Response To Nutrient
- Clathrin-mediated Endocytosis
- Virion Assembly
- Cell Migration
- Cytokinesis
- Cell Division
PTMs
Research Areas
- Apoptosis
- Mitochondrial-Mediated Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SH3GLB1
bosterbio.com/bosterbio-gene-info-cards/SH3GLB1
References
PMID: 11161816 by Pierrat B., et al. SH3GLB, a new endophilin-related protein family featuring an SH3 domain.
PMID: 11259440 by Cuddeback S.M., et al. Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax.