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SETX Antibodies
AND SETX ELISA kits, SETX Proteins
Many biological assays use antibodies to detect SETX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SETX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SETX antibodies...
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SETX Overview
Facts about Probable helicase senataxin.
Probable helicase senataxin (SETX)
Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224).
Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruiting and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805).
Gene Information
| Human | |
|---|---|
| Gene Name: | SETX |
| Uniprot: | Q7Z333 |
| Entrez: | 23064 |
Family
| Belongs to: |
|---|
| DNA2/NAM7 helicase family |
Alternative Names
ALS4recessive, non-Friedreich type 1; AOA2FLJ43459; DKFZp781B151; KIAA0625FLJ12840; senataxin; SETX
Molecular Weight
Mass (kDA):
302.88 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.13 |
| Sequence: | 9; NC_000009.12 (132261356..132356726, complement) |
Tissue Specificity
Highly expressed in skeletal muscle. Expressed in heart, fibroblast, placenta and liver. Weakly expressed in brain and lung. Expressed in the cortex of the kidney (highly expressed in tubular epithelial cells but low expression in the glomerulus).
Subcellular Localizations
Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Cytoplasm. Chromosome. Chromosome, telomere. Cell projection, axon. Cell projection, growth cone. May be detected in the nucleolus only in cycling cells. At pachytene stage, colocalizes predominantly to the heterochromatic XY-body of sex chromosomes with DNA damage response proteins in a BRCA1-dependent manner (By similarity). Localizes with telomeric DNA in a transcription-dependent manner (PubMed:21112256). Under replication stress, colocalizes with a variety of DNA damage signaling and repair response proteins at distinct nuclear foci in mi
Diseases
- Ataxia
- Apraxias
- Oculomotor Apraxia
- Cerebellar Ataxia
- Amyotrophic Lateral Sclerosis
- Atrophy
- Sclerosis
- Primary Lateral Sclerosis
- Oculomotor Nerve Paralysis
- Peripheral Neuropathy
- Neurodegenerative Disorders
- Ocular Motility Disorders
Interacting Proteins
- POLR2A
- SMN1
- UBE2I
Pathways
- Transport
- Rna Processing
- Dna Repair
- Translation
- Cell Death
- Vesicle Transport
- Programmed Cell Death
- Neuron Death
- Localization
- Myelination
- Response To Oxidative Stress
PTMs
- Cleavage
Research Areas
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SETX
bosterbio.com/bosterbio-gene-info-cards/SETX
References
PMID: 14770181 by Moreira M.-C., et al. Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia- ocular apraxia 2.
PMID: 17562789 by Suraweera A., et al. Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage.