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SETD1A Antibodies
AND SETD1A ELISA kits, SETD1A Proteins
Many biological assays use antibodies to detect SETD1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SETD1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SETD1A antibodies...
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SETD1A Infographic by Boster Bio
All SETD1A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
IHC, WB
$523
Cat # M03736
100 µl
Cat # M03736
100 µl
SETD1A Overview
Facts about Histone-lysine N-methyltransferase SETD1A.
Histone-lysine N-methyltransferase SETD1A (SETD1A)
Histone methyltransferase that specifically methylates'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SETD1A |
| Uniprot: | O15047 |
| Entrez: | 9739 |
Family
| Belongs to: |
|---|
| class V-like SAM-binding methyltransferase superfamily |
Alternative Names
histone-lysine N-methyltransferase SETD1A; hSET1A; KIAA0339EC 2.1.1.43; KMT2FSET1; Lysine N-methyltransferase 2F; SET domain containing 1A; SET domain-containing protein 1A; Set1; Set1/Ash2 histone methyltransferase complex subunit SET1; SET1A
Molecular Weight
Mass (kDA):
186.034 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p11.2 |
| Sequence: | 16; NC_000016.10 (30956618..30984664) |
Subcellular Localizations
Nucleus speckle. Chromosome. Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes.
Diseases
- Malignant Neoplasms
- Leukemia
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Instabilities, Chromosomal
- Mutation Abnormality
- Non-neoplastic Disorder
- Colonic Neoplasms
- Malignant Tumor Of Colon
- Degenerative Polyarthritis
- Carcinogenesis
- Carcinoma
Interacting Proteins
- Ctnnb1
- HCFC1
- RBBP5
Pathways
- Methylation
- Cell Cycle
- Histone Methylation
- Mitosis
- Gene Silencing
- Interphase
- Hypersensitivity
- M Phase
- Histone Modification
- Cell Cycle Arrest
- Cell Division
- Chromosome Decondensation
- Translation
PTMs
- Methylation
- Phosphorylation
- Demethylation
Research Areas
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SETD1A
bosterbio.com/bosterbio-gene-info-cards/SETD1A
References
PMID: 12670868 by Wysocka J., et al. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1.
PMID: 16253997 by Lee J.-H., et al. CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.