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- Table of Contents
Facts about Semaphorin-4D.
Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and enhances their viability (in vitro).
Human | |
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Gene Name: | SEMA4D |
Uniprot: | Q92854 |
Entrez: | 10507 |
Belongs to: |
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semaphorin family |
A8; BB18; CD100 antigen; CD100; CD100M-sema-G; COLL-4; FLJ33485; FLJ34282; FLJ39737; FLJ46484; immunoglobulin domain (Ig), transmembrane domain (TM) and shortcytoplasmic domain, 4D; MGC169138; MGC169141; M-sema-G; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and shortcytoplasmic domain, (semaphorin) 4D; SEMA4D; SEMAJ; Semaphorin 4D; semaphorin-4D
Mass (kDA):
96.15 kDA
Human | |
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Location: | 9q22.2 |
Sequence: | 9; NC_000009.12 (89360787..89498113, complement) |
Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.
Cell membrane; Single-pass type I membrane protein.
PMID: 8876214 by Hall K.T., et al. Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation.
PMID: 10520995 by Tamagnone L., et al. Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates.
*More publications can be found for each product on its corresponding product page