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- Table of Contents
Facts about Syntenin-2.
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Human | |
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Gene Name: | SDCBP2 |
Uniprot: | Q9H190 |
Entrez: | 27111 |
Belongs to: |
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No superfamily |
FLJ12256; SITAC18ST-2; syndecan binding protein (syntenin) 2; Syndecan-binding protein 2; syntenin-2
Mass (kDA):
31.594 kDA
Human | |
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Location: | 20p13 |
Sequence: | 20; NC_000020.11 (1309909..1329139, complement) |
Preferentially expressed in cells of the digestive tract (PubMed:11102519). Low expression in skeletal muscle and kidney (PubMed:11102519). Detected in differentiated keratinocytes of normal and malignant epithelium (PubMed:22623796). In healthy skin, expression is localized in suprabasal epidermal layers (PubMed:22623796).
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cell membrane. Nucleus speckle. Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519). Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519). Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997). PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061).
PMID: 11152476 by Koroll M., et al. The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self- associating activity.
PMID: 11102519 by Borrell-Pages M., et al. The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein.