SCNN1A Antibodies

AND SCNN1A ELISA kits, SCNN1A Proteins

Many biological assays use antibodies to detect SCNN1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SCNN1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SCNN1A antibodies...

We validate the specificity of these antibodies to SCNN1A by testing them on tissues known to express SCNN1A positively and negatively. Browse below to find the SCNN1A antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SCNN1A Infographic by Boster Bio

All SCNN1A Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-epithelial Sodium Channel alpha/SCNN1A Antibody Picoband®

1 Q&As

Human

IF, ICC, WB

$370
Cat # A01413-1
100 μg/vial

Anti-ENaC alpha Monoclonal Antibody

3 Q&As

Mouse, Rat

IHC, WB

$425
Cat # M01413
100ug

epithelial Sodium Channel alpha (SCNN1A) (NM_001038) Human Over-expression Lysate

Human

$628
Cat # LS006337
100 µg

Anti-epithelial Sodium Channel alpha/SCNN1A Antibody Picoband®

Human

ELISA, WB

$370
Cat # A01413-2
100 μg/vial

SCNN1A Overview

Facts about Amiloride-sensitive sodium channel subunit alpha.

SCNN1A 3D structure. Source: alphafold

Amiloride-sensitive sodium channel subunit alpha (SCNN1A)

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells.

Plays an important role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands.

Gene Information

Human
Gene Name:	SCNN1A
Uniprot:	P37088
Entrez:	6337

Family

Belongs to:

amiloride-sensitive sodium channel (TC 1.A.6) family

Alternative Names

alpha ENaC-2; alpha-ENaC; alpha-NaCH; amiloride-sensitive epithelial sodium channel alpha subunit; amiloride-sensitive sodium channel subunit alpha 2; amiloride-sensitive sodium channel subunit alpha; BESC2; ENaCa; ENaCalpha; Epithelial Na(+) channel subunit alpha; FLJ21883; nasal epithelial sodium channel alpha subunit; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; SCNN1; sodium channel, nonvoltage-gated 1 alpha

Molecular Weight

Mass (kDA):
75.704 kDA

Genomic Context


Human

Location:	12p13.31
Sequence:	12; NC_000012.12 (6346843..6377357, complement)

Tissue Specificity

Expressed in the female reproductive tract, from the fimbrial end of the fallopian tube to the endometrium (at protein level) (PubMed:22207244). Expressed in kidney (at protein level). In the respiratory tract, expressed in the bronchial epithelium (at protein level). Highly expressed in lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta (PubMed:22207244). in skin, expressed in keratinocytes, melanocytes and Merkel cells of the epidermal sub- layers, stratum basale, stratum spinosum and stratum granulosum (at protein level) (PubMed:28130590). Expressed in the outer root sheath of the hair follicles (at protein level) (PubMed:28130590). Detected in both peripheral and central cells of the sebaceous gland (at protein level) (PubMed:28130590). Expressed by eccrine sweat glands (at protein level) (PubMed:28130590). In skin, also expressed by arrector pili muscle cells and intradermal adipocytes (PubMed:28130590). Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart (PubMed:9575806).

Subcellular Localizations

Apical cell membrane; Multi-pass membrane protein. Cell projection, cilium. Cytoplasmic granule. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non-ciliated epithelial cells, restricted to apical surfaces. In epidermis, located nearly uniformly in the cytoplasm in a granular distribution (PubMed:28130590). In sebaceous glands, observed only in the cytoplasmic space in between the lipid vesicles (PubMed:28130590). In eccrine sweat glands, mainly located at the

Diseases

Hypertensive Disease
Pseudohypoaldosteronism
Cystic Fibrosis
Fibrosis
Liddle Syndrome
Pseudohypoaldosteronism, Type 1
Disease Of Adrenal Medulla
Dehydration
Edema
Neoplasms
Lung Diseases
Diabetes Mellitus

Epilepsy
Infantile Severe Myoclonic Epilepsy
Adenocarcinoma
Pulmonary Edema
Cardiovascular Diseases
Epilepsies, Myoclonic
Hypotension Adverse Event

Interacting Proteins

SCNN1G

Pathways

Transport
Localization
Secretion
Ion Transport
Methylation
Excretion
Dna Methylation
Pathogenesis
Cellular Ion Homeostasis
Chemotaxis
Hemostasis
Protein Transport
Glomerular Filtration

Ion Homeostasis
Coagulation
Water Homeostasis
Lymphocyte Activation
Cell Adhesion
Cell Migration
Dna Hypermethylation

PTMs

Cleavage
Methylation

Phosphorylation
Demethylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCNN1A

References

PMID: 8278374 by Voilley N., et al. The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning.

PMID: 8023962 by McDonald F.J., et al. Cloning, expression, and tissue distribution of a human amiloride- sensitive Na+ channel.