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- Table of Contents
Facts about Amiloride-sensitive sodium channel subunit alpha.
Plays an important role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands.
Human | |
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Gene Name: | SCNN1A |
Uniprot: | P37088 |
Entrez: | 6337 |
Belongs to: |
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amiloride-sensitive sodium channel (TC 1.A.6) family |
alpha ENaC-2; alpha-ENaC; alpha-NaCH; amiloride-sensitive epithelial sodium channel alpha subunit; amiloride-sensitive sodium channel subunit alpha 2; amiloride-sensitive sodium channel subunit alpha; BESC2; ENaCa; ENaCalpha; Epithelial Na(+) channel subunit alpha; FLJ21883; nasal epithelial sodium channel alpha subunit; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; SCNN1; sodium channel, nonvoltage-gated 1 alpha
Mass (kDA):
75.704 kDA
Human | |
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Location: | 12p13.31 |
Sequence: | 12; NC_000012.12 (6346843..6377357, complement) |
Expressed in the female reproductive tract, from the fimbrial end of the fallopian tube to the endometrium (at protein level) (PubMed:22207244). Expressed in kidney (at protein level). In the respiratory tract, expressed in the bronchial epithelium (at protein level). Highly expressed in lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta (PubMed:22207244). in skin, expressed in keratinocytes, melanocytes and Merkel cells of the epidermal sub- layers, stratum basale, stratum spinosum and stratum granulosum (at protein level) (PubMed:28130590). Expressed in the outer root sheath of the hair follicles (at protein level) (PubMed:28130590). Detected in both peripheral and central cells of the sebaceous gland (at protein level) (PubMed:28130590). Expressed by eccrine sweat glands (at protein level) (PubMed:28130590). In skin, also expressed by arrector pili muscle cells and intradermal adipocytes (PubMed:28130590). Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart (PubMed:9575806).
Apical cell membrane; Multi-pass membrane protein. Cell projection, cilium. Cytoplasmic granule. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non-ciliated epithelial cells, restricted to apical surfaces. In epidermis, located nearly uniformly in the cytoplasm in a granular distribution (PubMed:28130590). In sebaceous glands, observed only in the cytoplasmic space in between the lipid vesicles (PubMed:28130590). In eccrine sweat glands, mainly located at the
This article will explore Steven Boster's Historial background and the best uses of the SCNN1A marker. We will also look at how SCNN1A markers could be beneficial to scientists. We will also discuss the benefits of SCNN1A-based antibodies. We hope that you are enticed to use this marker. You will be thankful that you chose to use this marker.
Boster Bio is a supplier of high-affinity primary antibodies. The extensive product line of the company includes ELISA kits as well as buffers, lysates and ELISA reagents. The reagents it offers include human and mouse samples. For many research applications high-affinity primary antibody are essential. They are reliable and provide high-quality results. The company also makes its ELISA kits and antibodies in its own labs. These antibodies are optimized to ensure high-affinityand specificity and sensitivity.
The company also manufactures monoclonal and polyclonal antibody for the biomedical industry. The primary antibodies are suitable to detect plant proteins and are highly reactive with thousands of species of plants. They are highly effective in different applications and have been cited in over 5000 scientific papers. The company is a reputable supplier for high-affinity primary antibody. Its ELISA kits are specifically designed to be used by research institutions to detect a wide range of cellular and molecular proteins.
Among the high-affinity primary antibodies available on the market VHH-72 and CR3022 have shown promising neutralizing activity, although the two antibodies have only mildly different binding properties. CR3022's IC50 values were 0.0107 +-0.06 nM for 12H2 and 0.161 nM for 13I1, while CB6's were 0.109 +-0.04 nM for both proteins.
The primary antibodies are created by a variety of host immune systems. Their building blocks are called complementarity-determining regions. Read more about complementarity-determining regions on Wikipedia. Scientists develop polyclonal primary antibodies by immunizing a host animal with specific antigens then extracting the primary antibodies from the egg or serum of the animals. They then analyze, purify or detect antigens within the samples.
The company develops monoclonal as well as polyclonal antibodies for rabbits and chickens. Its process for making proteins is based on an eukaryotic expression device. Another company, Absea Biotechnology, produces monoclonal antibodies and fragments of Fab. It also offers customized antibody development services which include optimization, humanization, Fc, and Fv customization. The company also offers contract services to its clients.
The SCNN1A Marker could be used in ovarian cancer research to track the progression of the disease. In this study, patients were split into two groups: high-expressing SCNN1A and those with low-expressing SCNN1A. The results show a significant correlation between SCNN1A expression and immune infiltration. More studies are needed to confirm these findings and to better understand how SCNN1A influences immune infiltration in the ovary.
When comparing the two kinds of Scnn1A markers, the former is better suited to imaging the brain. The latter lets researchers analyze the distribution of Scnn1A-expressing cells. The Scnn1A marker performs better in identifying genes in the cortex than the SCNN1A-expressing cells. The RGCs expressed by the Scnn1A Marker cluster into ON transientstates, ON-OFF states.
SCNN1A expression is also associated with the infiltration of immune cells. This makes it an ideal biomarker for the study of ovarian cancer. It may also help in interpreting the results of other clinical studies. It might be used to determine if high SCNN1A expression is linked to poor outcomes. This study could provide further insights into the role SCNN1A is involved in ovarian cancer and help to establish the foundation for future research.
SCNN1A is an overexpressed gene can be found in ovarian carcinoma. In one study, it was associated with lower OS, PFS, and disease-specific survival. Kaplan-Meier analysis revealed that higher SCNN1A expression was linked to poorer OS and PFS. It was also associated with lower survival in subgroups. And, the SCNN1A marker correlated with the tumor status in the study of women suffering from an ovarian cancer.
PMID: 8278374 by Voilley N., et al. The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning.
PMID: 8023962 by McDonald F.J., et al. Cloning, expression, and tissue distribution of a human amiloride- sensitive Na+ channel.