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SCN5A Antibodies
AND SCN5A ELISA kits, SCN5A Proteins
Many biological assays use antibodies to detect SCN5A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SCN5A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SCN5A antibodies...
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SCN5A Overview
Facts about Sodium channel protein type 5 subunit alpha.
Sodium channel protein type 5 subunit alpha (SCN5A)
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1309946, PubMed:21447824, PubMed:25370050, PubMed:23420830, PubMed:23085483, PubMed:26279430, PubMed:26392562, PubMed:26776555).
It is a tetrodotoxin-resistant Na(+) channel isoform (PubMed:1309946). This channel is responsible for the initial upstroke of the action potential.
Gene Information
| Human | |
|---|---|
| Gene Name: | SCN5A |
| Uniprot: | Q14524 |
| Entrez: | 6331 |
Family
| Belongs to: |
|---|
| sodium channel (TC 1.A.1.10) family |
Alternative Names
cardiac sodium channel alpha subunit; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CDCD2VF1; HB1sodium channel, voltage-gated, type V, alpha (long QT syndrome 3); HB2; HBBD; HH1CMD1E; ICCD; IVF; LQT3SSS1CMPD2; Nav1.5; PFHB1; Sodium channel protein cardiac muscle subunit alpha; sodium channel protein type 5 subunit alpha; sodium channel protein type V alpha subunit; Sodium channel protein type V subunit alpha; sodium channel, voltage-gated, type V, alpha subunit; Voltage-gated sodium channel subunit alpha Nav1.5
Molecular Weight
Mass (kDA):
226.94 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p22.2 |
| Sequence: | 3; NC_000003.12 (38548061..38649687, complement) |
Tissue Specificity
Found in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Cell membrane, sarcolemma, T-tubule. RANGRF promotes trafficking to the cell membrane.
Diseases
- Cardiac Arrhythmia
- Long Qt Syndrome
- Brugada Syndrome (disorder)
- Sudden Cardiac Death
- Sudden Death
- Cardiac Fibrillation
- Ventricular Fibrillation
- Tachycardia, Ventricular
- Syncope
- Cardiac Death
- Heart Diseases
- Bundle-branch Block
- Atrial Fibrillation
Interacting Proteins
- CAMK2D
- PRMT1
- PRMT3
- PTPN3
Pathways
- Cardiac Conduction
- Pathogenesis
- Localization
- Transport
- Aging
- Translation
- Cell Proliferation
- Membrane Depolarization
- Cellular Localization
- Secretion
- Innervation
- Muscle Contraction
- Phagocytosis
PTMs
- Phosphorylation
- Biotinylation
- Nitrosylation
- Carboxylation
- Nitration
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCN5A
bosterbio.com/bosterbio-gene-info-cards/SCN5A
References
PMID: 1309946 by Gellens M.E., et al. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.
PMID: 12358675 by Ou Y., et al. SCN5A is expressed in human jejunal circular smooth muscle cells.