SCN1B Antibodies

AND SCN1B ELISA kits, SCN1B Proteins

Many biological assays use antibodies to detect SCN1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SCN1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SCN1B antibodies...

We validate the specificity of these antibodies to SCN1B by testing them on tissues known to express SCN1B positively and negatively. Browse below to find the SCN1B antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SCN1B Infographic by Boster Bio

All SCN1B Products

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Specificity

Applications

Price

Anti-Sodium channel subunit beta-1 SCN1B Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A03061
100ul

Anti-SCN1B Antibody Picoband®

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A03061-1
100 μg/vial

SCN1B (NM_001037) Human Over-expression Lysate

Human

$628
Cat # LS006324
100 µg

SCN1B Overview

Facts about Sodium channel subunit beta-1.

SCN1B 3D structure. Source: alphafold

Sodium channel subunit beta-1 (SCN1B)

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart.

Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and keep these channels at the nodes in mature myelinated axons. .

Gene Information

Human
Gene Name:	SCN1B
Uniprot:	Q07699
Entrez:	6324

Family

Belongs to:

sodium channel auxiliary subunit SCN1B (TC 8.A.17) family

Alternative Names

Sodium channel subunit beta-1

Molecular Weight

Mass (kDA):
24.707 kDA

Genomic Context


Human

Location:	19q13.11
Sequence:	19; NC_000019.10 (35030470..35040449)

Tissue Specificity

The overall expression of isoforms 1 and 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level).

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection. Cell projection, axon. Detected at nodes of Ranvier on the sciatic nerve.; [Isoform 2]: Perikaryon. Cell projection. Secreted. Detected on Purkinje cells and their cell projections and on neuronal cell projections.

Interacting Proteins

SCN4A

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCN1B

References

PMID: 8394762 by McClatchey A.I., et al. The cloning and expression of a sodium channel beta 1-subunit cDNA from human brain.

PMID: 8125980 by Makita N., et al. Voltage-gated Na+ channel beta 1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene.