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- Table of Contents
Facts about Sodium channel protein type 1 subunit alpha.
Plays a key role in brain, probably by modulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimulation.
Human | |
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Gene Name: | SCN1A |
Uniprot: | P35498 |
Entrez: | 6323 |
Belongs to: |
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sodium channel (TC 1.A.1.10) family |
Sodium channel protein type 1 subunit alpha
Mass (kDA):
228.972 kDA
Human | |
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Location: | 2q24.3 |
Sequence: | 2; NC_000002.12 (165984641..166149161, complement) |
Cell membrane; Multi-pass membrane protein.
PMID: 10742094 by Escayg A., et al. Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2.
PMID: 8062593 by Malo M.S., et al. Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24.
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