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Acyl-CoA desaturase Antibodies
AND SCD ELISA kits, Acyl-CoA desaturase Proteins
Many biological assays use antibodies to detect Acyl-CoA desaturase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Acyl-CoA desaturase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Acyl-CoA desaturase antibodies...
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SCD Infographic by Boster Bio
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SCD Overview
Facts about Acyl-CoA desaturase.
Acyl-CoA desaturase (SCD)
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to present the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond in the delta-9 place into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284).
Gives rise to a mix of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an essential role in lipid biosynthesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | SCD |
| Uniprot: | O00767 |
| Entrez: | 6319 |
Family
| Belongs to: |
|---|
| fatty acid desaturase type 1 family |
Alternative Names
FADS5; MSTP008; SCD1; SCD-1; SCDOS; Stearoyl-CoA desaturase
Molecular Weight
Mass (kDA):
41.523 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q24.31 |
| Sequence: | 10; NC_000010.11 (100347233..100364826) |
Tissue Specificity
Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Diseases
- Anemia, Sickle Cell
- Sudden Cardiac Death
- Cardiac Death
- Cardiac Arrhythmia
- Infarction
- Pain
- Heart Diseases
- Anemia
- Myocardial Infarction
- Cerebrovascular Accident
- Cardiomyopathies
- Tachycardia, Ventricular
- Hypertensive Disease
Pathways
- Pathogenesis
- Dehiscence
- Coagulation
- Cell Adhesion
- Transport
- Secretion
- Glomerular Filtration
- Cell Cycle
- Fatty Acid Oxidation
- Lactation
- Cell Proliferation
- Aging
- Localization
PTMs
- Phosphorylation
- Oxidation
- Cleavage
- Methylation
- Nitration
- Deacetylation
- Sulphation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCD
bosterbio.com/bosterbio-gene-info-cards/SCD
References
PMID: 10229681 by Zhang L., et al. Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites.
PMID: 11415448 by Zhang L., et al. Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element.