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SAFB Antibodies
AND SAFB ELISA kits, SAFB Proteins
Many biological assays use antibodies to detect SAFB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SAFB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SAFB antibodies...
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SAFB Infographic by Boster Bio
All SAFB Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$405
Cat # A03458
100ul
Cat # A03458
100ul
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M03458-1
100 μl/vial
Cat # M03458-1
100 μl/vial
SAFB Overview
Facts about Scaffold attachment factor B1.
Scaffold attachment factor B1 (SAFB)
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly stage to enable the formation of a'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription.
When associated with RBMX, binds to and stimulates transcription in the SREBF1 promoter (By similarity). Can inhibit cell proliferation.
Gene Information
| Human | |
|---|---|
| Gene Name: | SAFB |
| Uniprot: | Q15424 |
| Entrez: | 6294 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
glutathione S-transferase fusion protein; HAP; heat-shock protein (HSP27) estrogen response element and TATA box-bindingprotein; HETDKFZp779C1727; Hsp27 ERE-TATA binding protein; HSP27 ERE-TATA-binding protein; HSP27 estrogen response element-TATA box-binding protein; SAF-B; SAF-B1; SAFB1SAB-B1; scaffold attachment factor B; scaffold attachment factor B1
Molecular Weight
Mass (kDA):
102.642 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.3 |
| Sequence: | 19; NC_000019.10 (5623081..5668478) |
Tissue Specificity
Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Mutation, Out-of-frame
- Neoplasms, Experimental
- Werner Syndrome
- Bone Neoplasms
- Aneuploidy
- Immediate Hypersensitivity
Interacting Proteins
- FUS
- MAP1LC3B
- SAFB2
- Srek1
- TP53
Pathways
- Localization
- Cell Proliferation
- Rna Splicing
- Cell Growth
- Rna Processing
- Dna Repair
- Complement-dependent Cytotoxicity
- Cell Cycle
- Chromatin Organization
- Histone Deacetylation
- Induction Of Apoptosis
- Aging
- Anaphylaxis
PTMs
- Phosphorylation
- Sumoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SAFB
bosterbio.com/bosterbio-gene-info-cards/SAFB
References
PMID: 9328833 by Oesterreich S., et al. Novel nuclear matrix protein HET binds to and influences activity of the HSP27 promoter in human breast cancer cells.
PMID: 8600450 by Renz A., et al. Purification and molecular cloning of the scaffold attachment factor B (SAF-B), a novel human nuclear protein that specifically binds to S/MAR-DNA.