Protein S100-A4 Antibodies

Protein S100-A4 (S100A4)

Gene Information

Human
Gene Name:	S100A4
Uniprot:	P26447
Entrez:	6275

Family

Belongs to:
S-100 family

Alternative Names

18A2; 42A; Calvasculin; CAPL; CAPLS100 calcium binding protein A4 (calcium protein, calvasculin, metastasin; fibroblast-specific protein-1,42A; FSP1; leukemia multidrug resistance associated protein; malignant transformation suppression 1; Metastasin; MTS1; murine placental homolog); P9KA; PEL98; Placental calcium-binding protein; Protein Mts1; protein S100-A4; S100 calcium binding protein A4; S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog); S100 calcium-binding protein A4; S100A4

Molecular Weight

Mass (kDA):
11.729 kDA

Genomic Context

Human
Location:	1q21.3
Sequence:	1; NC_000001.11 (153543621..153545806, complement)

Tissue Specificity

Ubiquitously expressed.

Diseases

• Neoplasms
• Malignant Neoplasms
• Neoplasm Metastasis
• Carcinoma
• Cell Invasion
• Neoplasm Invasiveness
• Adenocarcinoma
• Fibrosis
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Malignant Paraganglionic Neoplasm
• Cell Transformation, Neoplastic
• Tissue Adhesions

• Tumor Progression
• Malignant Squamous Cell Neoplasm
• Inflammation
• Tumor Angiogenesis
• Lung Neoplasms
• Lymphatic Metastasis
• Pancreatic Neoplasm

Interacting Proteins

• AREG
• BTC
• MDM2
• MYH9
• S100A1

• S100B
• TP53

Pathways

• Cell Motility
• Pathogenesis
• Cell Proliferation
• Localization
• Angiogenesis
• Cell Migration
• Cell Cycle
• Methylation
• Secretion
• Cell Growth
• Cell Adhesion
• Regeneration
• Epithelial To Mesenchymal Transition

• Cell Death
• Rna Interference
• Dna Methylation
• Wound Healing
• Cell Differentiation
• Gene Silencing
• Immune Response

PTMs

• Phosphorylation
• Methylation
• Cleavage
• Reduction
• Demethylation
• Sumoylation
• Nitrosylation

• Glutathionylation
• Phosphorothioation
• Dephosphorylation
• Cysteinylation
• Ubiquitination
• Glycosylation
• Acetylation

• Oxidation

Research Areas

• Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/S100A4

Best Uses of the S100A4 Marker

Whether you're looking to conduct an experiment or test the effectiveness of a new product, Boster Bio's S100A4 marker can be your answer. This innovative, multichannel liquid dispensing system has the utmost versatility, making it easy to measure and analyze absorbance at 450 nm. If you're preparing to publish your results, the Boster Microplate Reader comes with a free product credit for each test you run.

Boster Bio: S100A4 Marker

Human S100A4 protein was expressed in E. coli. Biophysical characterization and functional assays indicated that the protein was highly reactive in E. coli and had good immunoreactivity. Functional investigation of S100A4 in human gastric cancer could be carried out with soluble mAbs. The mAbs may also be used for diagnostic and therapeutic strategies.

S100A4 is a polypeptide protein with 101 amino acids and a molecular weight of 11.5 kDa. It is associated with intracellular signal transduction, cell motility, and cell-cell communication. Its expression has been associated with tumor progression and survival and is involved in metastasis. Although S100A4 expression is not detected in normal tissue, cancer cells have high S100A4 expression.

The S100A4 monoclonal antibody from Boster Bio reacts with Human and Mouse S100A4 protein. The blocking peptide is available at 1.0 mg/l. Boster Bio antibodies have been validated on known positive and negative samples. This means that they will work reliably. Moreover, Boster scientists can submit their results and gain product credits by using Boster antibodies.

The S100A4 gene fragment was produced in E. coli using an overlapping polymerase chain reaction. A forward primer contained the Ndel restriction site, while a reverse primer had the Xhol restriction site. The construct was used to analyze human gastric carcinoma specimens. Recombinant S100A4 protein mAbs promoted the migration and invasion of HeLa cells.

Featured Products

Featured products of the Boster S 100A4 Marker are a new way to attract customers to your store. A featured product will be displayed on your store's homepage. To feature your product, simply create a short product description to tell customers what it is and what it does. The Boster Bio Anti-S100A4 Marker reacted with Human and Mouse.

Pricing

A new lung fibroblast marker, S100A4, has been identified. This gene may be useful in the study of pulmonary fibrosis. The overexpression of S100A4 is associated with a poorer prognosis in cancer patients. Therefore, pricing of the S100A4 Marker may be important. Here, we will review pricing trends for this gene and discuss its potential utility in the development of lung cancer drugs.

Availability

The Availability of the S100A4 Markers in Humans may provide a valuable insight into the development and progression of many fibrotic diseases. This gene regulates a number of cellular functions and binds several target molecules. It is also involved in neuroprotection and plays a role in angiogenesis. In addition to being involved in immune functions, S100A4 promotes cell motility and proliferation.

S100A4 is classified as a metastasis-associated protein (MAP), and is also referred to as metastasin, 18A2, and calvasculin. It is found on chromosome 1q21 and contains four exons encoding its Ca2+-binding region. Its molecular mass is 12.3 kDa and isoelectric point is 5.59. This protein also interacts with a variety of target proteins, including tropomyosin and actin.

The Availability of the S100A4 Markers in Humans has been linked to poor treatment outcomes in several diseases, including osteoarthritis. The S100A4 protein is secreted by various types of cells, including neurons and glia. It regulates gene expression associated with angiogenesis, proteolytic activity, and cell survival. It also modulates signaling pathways involving MAPKs, p38, Jun N-terminal kinases, and nuclear factor-kappa B.

The S100A4 gene is implicated in the inflammatory process in several neurological disorders. It is involved in the inflammatory response that precedes neuronal loss. Furthermore, S100A4 is found in astrocytes in a transgenic SOD1-G93A animal model. S100A4 is also present in activated primary microglia. It has been shown to contribute to reactive gliosis and the formation of a "glial scar".

The S100A4 gene is a member of the S100 family of proteins. More than twenty members of the S100 family have been identified. The proteins share fifty percent amino acid sequences and are distributed in various organs and tissues. They are characterized by a motif, the EF-hand, that suggests that the genes shared a common ancestor. The S100A4 gene encodes an X-type four-helix bundle that is symmetric and comprises noncovalent interactions between two helices from each subunit.

Frequently Asked Questions

S100A4 is a protein that forms oligomers in its outer environment. These oligomers interact with multiple cell surface receptors. Members of the S100 family include RAGE, Toll-like receptor 4, EGFR, IL-10 receptor, annexin-A2, and tyrosine kinase. Whether this protein has a specific role in the body remains to be determined.

While S100A4 has been shown to be associated with tumor development, it also has a prognostic role in metastatic cancer. Specifically, S100A4 controls various cellular pathways and exerts numerous effects on various processes. These effects depend on cell and tissue type, and are thought to promote tumor invasion, cytoskeletal dynamics, and pro-inflammatory phenotypes.

The S100A4 protein has numerous extracellular and intracellular functions. It is implicated in various pathological conditions affecting the nervous system. In particular, S100A4 expression is frequently dramatically elevated in the CNS and PNS. While its function is not fully understood, it is important in disease progression. Further, the gene is essential for regulating neuronal plasticity, and may be involved in diseases affecting the nervous system.

Because of its multifaceted roles in various cancers, the S100A4 marker has been studied extensively. More attention has been focused on the soluble S100A4 variant in recent years. In contrast, extracellular S100A4 is elevated at sites of inflammation in fibrotic diseases. It serves as a DAMP protein, promoting sustained inflammation and destruction of organ structure. This makes it an excellent biomarker for assessing disease activity.