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Protein S100-A12 Antibodies
AND S100A12 ELISA kits, Protein S100-A12 Proteins
Many biological assays use antibodies to detect Protein S100-A12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein S100-A12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein S100-A12 antibodies...
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S100A12 Infographic by Boster Bio
All S100A12 Products
Product
Figures
Specificity
Applications
Price
Human S100A12/En Rage ELISA Kit PicoKine®
2 Citations 11 Q&As
Human
ELISA
$450
Cat # EK1169
96 wells/kit, with removable strips.
Cat # EK1169
96 wells/kit, with removable strips.
Human
$250
Cat # PROTP80511
2ug, 10ug, 1mg
Cat # PROTP80511
2ug, 10ug, 1mg
S100A12 Overview
Facts about Protein S100-A12.
Protein S100-A12 (S100A12)
S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration.
Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells through binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1.
Gene Information
| Human | |
|---|---|
| Gene Name: | S100A12 |
| Uniprot: | P80511 |
| Entrez: | 6283 |
Family
| Belongs to: |
|---|
| S-100 family |
Alternative Names
CAAF1; CAAF1Neutrophil S100 protein; CAAFI; CAGC; CAGCS100 calcium binding protein A12 (calgranulin C); CAGCS100; Calcium-binding protein in amniotic fluid 1; Calgranulin C; calgranulin-C; CGRPEN-RAGE; ENRAGE; EN-RAGE; Extracellular newly identified RAGE-binding protein; MRP6; p6calgranulin C; protein S100-A12; S100 calcium binding protein A12; S100 calcium-binding protein A12 (calgranulin C); S100 calcium-binding protein A12; S100A12
Molecular Weight
Mass (kDA):
10.575 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.3 |
| Sequence: | 1; NC_000001.11 (153373711..153375621, complement) |
Tissue Specificity
Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease.
Subcellular Localizations
Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.
Diseases
- Inflammation
- Arthritis
- Rheumatoid Arthritis
- Inflammatory Bowel Diseases
- Intestinal Diseases
- Tissue Adhesions
- Ulcer
- Atherosclerosis
- Crohn Disease
- Neoplasms
- Infective Disorder
- Colitis
- Mucocutaneous Lymph Node Syndrome
Pathways
- Pathogenesis
- Inflammatory Response
- Immune Response
- Localization
- Secretion
- Cell Adhesion
- Neutrophil Activation
- Cell Differentiation
- Cell Activation
- Excretion
- Cell Growth
- Regulation Of Protein Phosphorylation
- Mast Cell Activation
PTMs
- Phosphorylation
- Carboxylation
- Glycosylation
- Citrullination
- Ubiquitination
Research Areas
- Cancer
- Cytokine Research
- Immunology
- Innate Immunity
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/S100A12
bosterbio.com/bosterbio-gene-info-cards/S100A12
References
PMID: 8619860 by Yamamura T., et al. Human CAAF1 gene -- molecular cloning, gene structure, and chromosome mapping.
PMID: 8985590 by Wicki R., et al. Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21.
2 Publications of Boster Protein S100-A12 Antibodies & ELISA Kits
- PubMed ID: 10.2147/CIA.S309082, Effects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cogni...
- PubMed ID: 33976542, Liu T,Yin C,Li Y,Gao F,Yu L,Wang Z,Wang Q.Effects of Transcutaneous Electrical A...
*More publications can be found for each product on its corresponding product page