Ryanodine receptor 1 Antibodies

Calcium channel that mediates the release of Ca(2+) in the sarcoplasmic reticulum into the cytoplasm and thereby plays an integral role in triggering muscle contraction after depolarization of T-tubules (PubMed:11741831, PubMed:16163667). Repeated very high-level exercise increases the open probability of the channel and contributes to Ca(2+) leaking into the cytoplasm (PubMed:18268335).

Can also mediate the release of Ca(2+) from intracellular stores in neurons, and might thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle.