RYK Antibodies

AND RYK ELISA kits, RYK Proteins

Many biological assays use antibodies to detect RYK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RYK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RYK antibodies...

We validate the specificity of these antibodies to RYK by testing them on tissues known to express RYK positively and negatively. Browse below to find the RYK antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RYK Infographic by Boster Bio

All RYK Products

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Product

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Specificity

Applications

Price

Anti-Tyrosine-protein kinase RYK RYK Antibody

Human, Mouse

ELISA, WB

$380
Cat # A07225
100ul

RYK (NM_002958) Human Recombinant Protein

$1062
Cat # PROTP34925
20 µg

Anti-RYK Antibody

Human

Flow Cytometry, WB

$299
Cat # M07225
50 µl

Anti-RYK Rabbit Monoclonal Antibody

Human

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M07225-1
100 μl/vial

RYK Overview

Facts about Tyrosine-protein kinase RYK.

RYK 3D structure. Source: alphafold

Tyrosine-protein kinase RYK (RYK)

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A.
Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth.

In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm into the nucleus where it plays a vital role in neuronal development. .

Gene Information

Human
Gene Name:	RYK
Uniprot:	P34925
Entrez:	6259

Family

Belongs to:

protein kinase superfamily

Alternative Names

D3S3195; EC 2.7.10; EC 2.7.10.1; hydroxyaryl-protein kinase; JTK5; JTK5A protein tyrosine kinase; JTK5A; RYK receptor-like tyrosine kinase; Ryk; RYK1; tyrosine-protein kinase RYK

Molecular Weight

Mass (kDA):
67.815 kDA

Genomic Context


Human

Location:	3q22.2
Sequence:	3; NC_000003.12 (134157133..134250859, complement)

Tissue Specificity

Observed in all the tissues examined.

Subcellular Localizations

Membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.

Diseases

Malignant Neoplasms
Nervousness
Neoplasms
Tissue Adhesions
Malignant Neoplasm Of Stomach
Colorectal Cancer
Carcinoma
Dysembryoplastic Neuroepithelial Tumor
Epithelial Ovarian Cancer
Ovarian Neoplasm
Cleft Palate
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Ovary

Malignant Neoplasm Of Pancreas
Cell Invasion
Malignant Neoplasm Of Prostate
Stomach Neoplasms
Spinal Cord Injuries
Carcinogenesis
Leukemia

Pathways

Axon Guidance
Localization
Cell Proliferation
Gastrulation
Regeneration
Cell Adhesion
Cell Migration
Neurogenesis
Pathogenesis
Brain Development
Axon Regeneration
Muscle Attachment
Cell Differentiation

Convergent Extension
Osteoblast Differentiation
Tube Formation
Cell Fate Determination
System Development
Glycosylation
Endocytosis

PTMs

Phosphorylation
Cleavage
Glycosylation

Ubiquitination
Reduction
Dephosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RYK

References

PMID: 8386829 by Stacker S.A., et al. Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK).

PMID: 8390040 by Tamagnone L., et al. The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain.