Regulator of telomere elongation helicase 1 (RTEL1)

ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis.

Regulates meiotic recombination and crossover homeostasis by dissociating strand intrusion occasions and thereby promotes noncrossover fix by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Additionally disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.