RTEL1 Antibodies

Regulator of telomere elongation helicase 1 (RTEL1)

ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis.

Regulates meiotic recombination and crossover homeostasis by dissociating strand intrusion occasions and thereby promotes noncrossover fix by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Additionally disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.

Gene Information

Human
Gene Name:	RTEL1
Uniprot:	Q9NZ71
Entrez:	51750

Family

Belongs to:
helicase family

Alternative Names

C20orf41; regulator of telomere elongation helicase 1; regulator of telomere length

Molecular Weight

Mass (kDA):
133.683 kDA

Genomic Context

Human
Location:	20q13.33
Sequence:	20; NC_000020.11 (63657810..63696253)

Subcellular Localizations

Nucleus. Colocalizes with PCNA within the replication foci in S-phase cells.

Diseases

• Glioma
• Neoplasms
• Brain Neoplasms
• Malignant Neoplasms
• Glioblastoma
• Genomic Instability
• Astrocytoma
• Allergy
• Dysequilibrium Syndrome
• Cell Transformation, Neoplastic
• Malignant Paraganglionic Neoplasm
• Sclerosis
• Fracture Of First Cervical Vertebra

• Anaplastic Astrocytoma
• Premature Aging Syndrome
• Aneuploidy
• Carcinoma
• Asthma
• Steroid Sulfatase Deficiency Disease
• Malignant Neoplasm Of Ovary

Pathways

• Dna Repair
• Dna Replication
• Double-strand Break Repair
• Telomere Maintenance
• S Phase
• Cell Proliferation
• Menopause
• Dna Recombination
• Metaphase
• Methylation
• Diakinesis

• Cell Cycle
• Cell Death
• Meiotic Cell Cycle
• Menarche
• Meiosis

PTMs

• Methylation

• Ribosylation

Research Areas

• Cancer
• DNA Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RTEL1

Boster Bio: Best Uses of the RTEL1 Marker

High-connectivity DEPs are necessary for high-throughput screening. This article will discuss the differences between these markers, and other DEPs. Boster Bio: The Best Uses of the RTEL1 Marker

DEPs with high-connectivity

The study of high-connectivity DEPs in Boster bio is the first of its kind. This study was designed to identify the functions of DEPs as well as their regulation in different tissues. High-connectivity DEPs were genes with high-degree association with cellular parts. These DEPs were identified as important in many processes, including fibronectin (Q63844) and actin (P50580). Other up and down-regulated proteins included mitogen-activated protein kinase 3 (Q63844) and proliferation-associated protein 2G4 (P50580). We also used a GO-annotated database to analyze the function of these DEPs. These GO annotated protein sequences include cellular components like the cytoplasmic membrane.

DEPs can be described as altered proteins that possess functional properties that are critical for the body’s functions. These proteins reside in different subcellular components. The enrichment rates in the three KEGG KEGG categories were calculated. The numbers displayed above the bar graphs represent the number DEPs. The study also revealed a novel molecular target for Ang II, RasGRF2.

High-connectivity RTEL1

The high-connectivity RTEL1 marker in the Boster bio dataset is a novel molecular genetic marker that has been found to be associated with numerous cellular processes. These include the MAPK–Erk, STAT, and FA biosynthesis pathways. It has also been shown that the marker is related to the apoptosis pathway and the PPAR family.